Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3956021..3957242 Replicon chromosome
Accession NZ_CP116721
Organism Pseudomonas aeruginosa strain 2867

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag PMJ93_RS18490 Protein ID WP_003110488.1
Coordinates 3956664..3957242 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PMJ93_RS18485 Protein ID WP_003088112.1
Coordinates 3956021..3956575 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMJ93_RS18460 (PMJ93_18460) 3951589..3952140 + 552 WP_003450159.1 XRE family transcriptional regulator -
PMJ93_RS18465 (PMJ93_18465) 3952137..3952535 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
PMJ93_RS18470 (PMJ93_18470) 3952548..3952871 - 324 WP_015648646.1 multidrug efflux SMR transporter -
PMJ93_RS18475 (PMJ93_18475) 3953202..3953663 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
PMJ93_RS18480 (PMJ93_18480) 3953668..3955863 + 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PMJ93_RS18485 (PMJ93_18485) 3956021..3956575 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
PMJ93_RS18490 (PMJ93_18490) 3956664..3957242 + 579 WP_003110488.1 HD domain-containing protein Toxin
PMJ93_RS18495 (PMJ93_18495) 3957351..3958538 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
PMJ93_RS18500 (PMJ93_18500) 3958528..3960699 - 2172 WP_025297367.1 type I secretion system permease/ATPase -
PMJ93_RS18505 (PMJ93_18505) 3960689..3961966 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T269183 WP_003110488.1 NZ_CP116721:3956664-3957242 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT269183 WP_003088112.1 NZ_CP116721:3956021-3956575 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References