269182

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 2935670..2936712 Replicon chromosome
Accession NZ_CP116721
Organism Pseudomonas aeruginosa strain 2867

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag PMJ93_RS13915 Protein ID WP_003153636.1
Coordinates 2936137..2936712 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag PMJ93_RS13910 Protein ID WP_003050245.1
Coordinates 2935670..2936140 (+) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMJ93_RS13875 (PMJ93_13875) 2931062..2932480 - 1419 WP_006226029.1 TIGR03752 family integrating conjugative element protein -
PMJ93_RS13880 (PMJ93_13880) 2932470..2933381 - 912 WP_006226028.1 TIGR03749 family integrating conjugative element protein -
PMJ93_RS13885 (PMJ93_13885) 2933378..2934070 - 693 WP_003090182.1 TIGR03746 family integrating conjugative element protein -
PMJ93_RS13890 (PMJ93_13890) 2934067..2934465 - 399 WP_003050133.1 TIGR03750 family conjugal transfer protein -
PMJ93_RS13895 (PMJ93_13895) 2934477..2934836 - 360 WP_003090173.1 TIGR03745 family integrating conjugative element membrane protein -
PMJ93_RS13900 (PMJ93_13900) 2934853..2935086 - 234 WP_023101201.1 TIGR03758 family integrating conjugative element protein -
PMJ93_RS13905 (PMJ93_13905) 2935083..2935466 - 384 WP_003090167.1 RAQPRD family integrative conjugative element protein -
PMJ93_RS13910 (PMJ93_13910) 2935670..2936140 + 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
PMJ93_RS13915 (PMJ93_13915) 2936137..2936712 + 576 WP_003153636.1 PIN domain-containing protein Toxin
PMJ93_RS13920 (PMJ93_13920) 2936730..2937644 + 915 WP_016852809.1 AAA family ATPase -
PMJ93_RS13925 (PMJ93_13925) 2937641..2938111 + 471 WP_003090160.1 type III CBASS phage resistance system CD-NTase-associated protein Cap8 -
PMJ93_RS13930 (PMJ93_13930) 2938108..2938608 + 501 WP_003090159.1 type III CBASS phage resistance system CD-NTase-associated protein Cap7 -
PMJ93_RS13935 (PMJ93_13935) 2938608..2939510 + 903 WP_003090158.1 CBASS oligonucleotide cyclase -
PMJ93_RS13940 (PMJ93_13940) 2939549..2940274 + 726 WP_003050273.1 CBASS effector endonuclease NucC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2921421..2948978 27557


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21629.78 Da        Isoelectric Point: 5.9995

>T269182 WP_003153636.1 NZ_CP116721:2936137-2936712 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT269182 WP_003050245.1 NZ_CP116721:2935670-2936140 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References