Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2638632..2639148 Replicon chromosome
Accession NZ_CP116721
Organism Pseudomonas aeruginosa strain 2867

Toxin (Protein)


Gene name relE Uniprot ID A0A3R8UIH5
Locus tag PMJ93_RS12570 Protein ID WP_025297453.1
Coordinates 2638867..2639148 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3R8UIM7
Locus tag PMJ93_RS12565 Protein ID WP_025297454.1
Coordinates 2638632..2638877 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMJ93_RS12545 (PMJ93_12545) 2633754..2634083 - 330 WP_031692728.1 hypothetical protein -
PMJ93_RS12550 (PMJ93_12550) 2634431..2635099 + 669 WP_071534660.1 hypothetical protein -
PMJ93_RS12555 (PMJ93_12555) 2635096..2636202 + 1107 WP_025297456.1 XRE family transcriptional regulator -
PMJ93_RS12560 (PMJ93_12560) 2636333..2638474 + 2142 WP_025297455.1 hypothetical protein -
PMJ93_RS12565 (PMJ93_12565) 2638632..2638877 + 246 WP_025297454.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
PMJ93_RS12570 (PMJ93_12570) 2638867..2639148 + 282 WP_025297453.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PMJ93_RS12575 (PMJ93_12575) 2639554..2640135 - 582 WP_033895412.1 plasmid pRiA4b ORF-3 family protein -
PMJ93_RS12580 (PMJ93_12580) 2640149..2641024 - 876 WP_033895413.1 WYL domain-containing protein -
PMJ93_RS12585 (PMJ93_12585) 2641153..2642733 + 1581 WP_063837559.1 DNA recombination protein RmuC -
PMJ93_RS12590 (PMJ93_12590) 2642757..2643149 + 393 WP_227274803.1 hypothetical protein -
PMJ93_RS12595 (PMJ93_12595) 2643133..2643405 + 273 WP_227274804.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2624383..2691512 67129


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-71)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10824.61 Da        Isoelectric Point: 10.6249

>T269181 WP_025297453.1 NZ_CP116721:2638867-2639148 [Pseudomonas aeruginosa]
MTYELEFLPSALKEWQKLGHTVREQIKKKLRERLDNPKVQADALRDMPGHYKIKLRASGYRLVYRVEDERVVVVVVAVGK
RERGAAYQSAKGR

Download         Length: 282 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8797.21 Da        Isoelectric Point: 4.2550

>AT269181 WP_025297454.1 NZ_CP116721:2638632-2638877 [Pseudomonas aeruginosa]
MQSILADVAVSVSELKKNPSGILAGAGGMPVAVLNHNRVMGYMVPAELYEQMMERLDDLELVEIVKARSGEESVPVRLDD
L

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R8UIH5

Antitoxin

Source ID Structure
AlphaFold DB A0A3R8UIM7

References