Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 2051861..2053369 Replicon chromosome
Accession NZ_CP116721
Organism Pseudomonas aeruginosa strain 2867

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag PMJ93_RS09600 Protein ID WP_003119682.1
Coordinates 2051861..2052448 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A6V2F0
Locus tag PMJ93_RS09605 Protein ID WP_012074952.1
Coordinates 2052515..2053369 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMJ93_RS09595 (PMJ93_09595) 2048116..2051595 - 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
PMJ93_RS09600 (PMJ93_09600) 2051861..2052448 + 588 WP_003119682.1 GNAT family protein Toxin
PMJ93_RS09605 (PMJ93_09605) 2052515..2053369 + 855 WP_012074952.1 AraC family transcriptional regulator Antitoxin
PMJ93_RS09610 (PMJ93_09610) 2053465..2055630 + 2166 WP_025297505.1 TonB-dependent receptor family protein -
PMJ93_RS09615 (PMJ93_09615) 2055805..2057679 + 1875 WP_003117607.1 MFS transporter -
PMJ93_RS09620 (PMJ93_09620) 2057740..2057949 - 210 WP_003115568.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

DNA binding HTH domain, AraC-type

(196-273)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T269180 WP_003119682.1 NZ_CP116721:2051861-2052448 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

>T269180 NZ_CP116721:2051861-2052448 [Pseudomonas aeruginosa]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTCGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGGCGTTGCCGCTCGCCGTCCGCCTCGGCGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAATTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGCGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGAGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGCGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31788.11 Da        Isoelectric Point: 7.7066

>AT269180 WP_012074952.1 NZ_CP116721:2052515-2053369 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSGFALVFIEQGAQRFRHRGGEHLAPWGSMVLINPDEVHTGSK
AHDSGWLYRGYYPEVEQIASILDELEIRHGGVPRFADSVVHDQPLARAFVHLHRLLADHAGSLETQTCWRETLLALFRRH
ARLPEAPKAGSEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKNGRA
PLDVALELGFADQSHLGRQFKQAYGVAPGEYRAACARSSLTMCE

Download         Length: 855 bp

>AT269180 NZ_CP116721:2052515-2053369 [Pseudomonas aeruginosa]
GTGCCGGACGAGACGAGCGGAGAACATACGCATTTCTGGCGCGCCGCCGAACTGGGCGGCGTCGAGTTGCTGCATGCGCG
CTACGTCGAGCAGCGTTTCGCCCCCCATGTGCACAGCGGCTTCGCCCTGGTCTTCATCGAGCAGGGCGCGCAGCGCTTCC
GCCATCGCGGCGGCGAGCACCTGGCGCCCTGGGGCAGCATGGTGCTGATCAACCCCGACGAAGTGCACACCGGCTCCAAG
GCCCATGACTCCGGCTGGCTCTATCGCGGCTACTACCCGGAGGTGGAGCAGATCGCCAGTATCCTCGACGAGCTGGAAAT
CCGCCACGGCGGGGTGCCGCGTTTCGCCGACAGCGTGGTCCATGACCAGCCCCTGGCGCGCGCCTTCGTCCATCTGCACC
GCTTGCTGGCCGACCACGCCGGCAGCCTGGAAACCCAGACCTGCTGGCGCGAGACGCTGCTCGCCCTGTTCCGTCGCCAC
GCCCGCCTGCCGGAGGCGCCGAAGGCCGGGTCGGAACCGTTGGCGGTCGCCCGCGCCCGCGAGTTGCTGGCGGCGCGTTT
GCTCGACCCGCCGTCGCTGGAAGAACTGGCGGCTGCGGTGAATCTGTCGCCGTTCCACTTCGCCCGGGTGTTCCGCCGCG
CCACCGGGATGCCGCCGCATGCCTGGCTCCGGCAACGGCGCCTGGAACAGGCCAGGGCGCTGCTCAAGAATGGCCGGGCG
CCGCTGGATGTCGCCCTGGAACTGGGCTTCGCCGACCAGAGCCATCTCGGTCGCCAGTTCAAGCAGGCCTACGGCGTGGC
GCCGGGCGAGTACCGCGCGGCCTGTGCGCGCTCGTCCTTGACGATGTGCGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A6V2F0

References