Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 164735..165240 Replicon chromosome
Accession NZ_CP116721
Organism Pseudomonas aeruginosa strain 2867

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag PMJ93_RS00795 Protein ID WP_003083773.1
Coordinates 164735..165016 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag PMJ93_RS00800 Protein ID WP_003083775.1
Coordinates 165013..165240 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMJ93_RS00770 (PMJ93_00770) 159986..161335 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
PMJ93_RS00775 (PMJ93_00775) 161384..162070 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
PMJ93_RS00780 (PMJ93_00780) 162171..162905 + 735 WP_004346926.1 GntR family transcriptional regulator -
PMJ93_RS00785 (PMJ93_00785) 163085..163495 + 411 WP_003101225.1 aegerolysin family protein -
PMJ93_RS00790 (PMJ93_00790) 163527..164435 - 909 WP_003083769.1 LysR family transcriptional regulator -
PMJ93_RS00795 (PMJ93_00795) 164735..165016 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
PMJ93_RS00800 (PMJ93_00800) 165013..165240 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
PMJ93_RS00805 (PMJ93_00805) 165416..166036 - 621 WP_003101226.1 hypothetical protein -
PMJ93_RS00810 (PMJ93_00810) 166137..166637 + 501 WP_003101228.1 LEA type 2 family protein -
PMJ93_RS00815 (PMJ93_00815) 166710..167051 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
PMJ93_RS00820 (PMJ93_00820) 167133..168560 - 1428 WP_003083784.1 GABA permease -
PMJ93_RS00825 (PMJ93_00825) 168729..170222 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T269179 WP_003083773.1 NZ_CP116721:c165016-164735 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT269179 WP_003083775.1 NZ_CP116721:c165240-165013 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References