Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3929632..3930853 Replicon chromosome
Accession NZ_CP116720
Organism Pseudomonas aeruginosa strain 2866

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag PMJ84_RS18360 Protein ID WP_003110488.1
Coordinates 3930275..3930853 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PMJ84_RS18355 Protein ID WP_003088112.1
Coordinates 3929632..3930186 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMJ84_RS18330 (PMJ84_18330) 3925200..3925751 + 552 WP_003450159.1 XRE family transcriptional regulator -
PMJ84_RS18335 (PMJ84_18335) 3925748..3926146 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
PMJ84_RS18340 (PMJ84_18340) 3926159..3926482 - 324 WP_015648646.1 multidrug efflux SMR transporter -
PMJ84_RS18345 (PMJ84_18345) 3926813..3927274 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
PMJ84_RS18350 (PMJ84_18350) 3927279..3929474 + 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PMJ84_RS18355 (PMJ84_18355) 3929632..3930186 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
PMJ84_RS18360 (PMJ84_18360) 3930275..3930853 + 579 WP_003110488.1 HD domain-containing protein Toxin
PMJ84_RS18365 (PMJ84_18365) 3930962..3932149 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
PMJ84_RS18370 (PMJ84_18370) 3932139..3934310 - 2172 WP_025297367.1 type I secretion system permease/ATPase -
PMJ84_RS18375 (PMJ84_18375) 3934300..3935577 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T269175 WP_003110488.1 NZ_CP116720:3930275-3930853 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT269175 WP_003088112.1 NZ_CP116720:3929632-3930186 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References