269174

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 2888104..2889146 Replicon chromosome
Accession NZ_CP116720
Organism Pseudomonas aeruginosa strain 2866

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag PMJ84_RS13690 Protein ID WP_003153636.1
Coordinates 2888571..2889146 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag PMJ84_RS13685 Protein ID WP_003050245.1
Coordinates 2888104..2888574 (+) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMJ84_RS13650 (PMJ84_13650) 2883496..2884914 - 1419 WP_006226029.1 TIGR03752 family integrating conjugative element protein -
PMJ84_RS13655 (PMJ84_13655) 2884904..2885815 - 912 WP_006226028.1 TIGR03749 family integrating conjugative element protein -
PMJ84_RS13660 (PMJ84_13660) 2885812..2886504 - 693 WP_003090182.1 TIGR03746 family integrating conjugative element protein -
PMJ84_RS13665 (PMJ84_13665) 2886501..2886899 - 399 WP_003050133.1 TIGR03750 family conjugal transfer protein -
PMJ84_RS13670 (PMJ84_13670) 2886911..2887270 - 360 WP_003090173.1 TIGR03745 family integrating conjugative element membrane protein -
PMJ84_RS13675 (PMJ84_13675) 2887287..2887520 - 234 WP_023101201.1 TIGR03758 family integrating conjugative element protein -
PMJ84_RS13680 (PMJ84_13680) 2887517..2887900 - 384 WP_003090167.1 RAQPRD family integrative conjugative element protein -
PMJ84_RS13685 (PMJ84_13685) 2888104..2888574 + 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
PMJ84_RS13690 (PMJ84_13690) 2888571..2889146 + 576 WP_003153636.1 PIN domain-containing protein Toxin
PMJ84_RS13695 (PMJ84_13695) 2889164..2890078 + 915 WP_016852809.1 AAA family ATPase -
PMJ84_RS13700 (PMJ84_13700) 2890075..2890545 + 471 WP_003090160.1 type III CBASS phage resistance system CD-NTase-associated protein Cap8 -
PMJ84_RS13705 (PMJ84_13705) 2890542..2891042 + 501 WP_003090159.1 type III CBASS phage resistance system CD-NTase-associated protein Cap7 -
PMJ84_RS13710 (PMJ84_13710) 2891042..2891944 + 903 WP_003090158.1 CBASS oligonucleotide cyclase -
PMJ84_RS13715 (PMJ84_13715) 2891983..2892708 + 726 WP_003050273.1 CBASS effector endonuclease NucC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21629.78 Da        Isoelectric Point: 5.9995

>T269174 WP_003153636.1 NZ_CP116720:2888571-2889146 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT269174 WP_003050245.1 NZ_CP116720:2888104-2888574 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References