Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2595638..2596154 Replicon chromosome
Accession NZ_CP116720
Organism Pseudomonas aeruginosa strain 2866

Toxin (Protein)


Gene name relE Uniprot ID A0A3R8UIH5
Locus tag PMJ84_RS12375 Protein ID WP_025297453.1
Coordinates 2595873..2596154 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3R8UIM7
Locus tag PMJ84_RS12370 Protein ID WP_025297454.1
Coordinates 2595638..2595883 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMJ84_RS12350 (PMJ84_12350) 2590760..2591089 - 330 WP_031692728.1 hypothetical protein -
PMJ84_RS12355 (PMJ84_12355) 2591437..2592105 + 669 WP_071534660.1 hypothetical protein -
PMJ84_RS12360 (PMJ84_12360) 2592102..2593208 + 1107 WP_025297456.1 XRE family transcriptional regulator -
PMJ84_RS12365 (PMJ84_12365) 2593339..2595480 + 2142 WP_025297455.1 hypothetical protein -
PMJ84_RS12370 (PMJ84_12370) 2595638..2595883 + 246 WP_025297454.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
PMJ84_RS12375 (PMJ84_12375) 2595873..2596154 + 282 WP_025297453.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PMJ84_RS12380 (PMJ84_12380) 2596560..2597141 - 582 WP_033895412.1 plasmid pRiA4b ORF-3 family protein -
PMJ84_RS12385 (PMJ84_12385) 2597155..2598030 - 876 WP_033895413.1 WYL domain-containing protein -
PMJ84_RS12390 (PMJ84_12390) 2598159..2599739 + 1581 WP_063837559.1 DNA recombination protein RmuC -
PMJ84_RS12395 (PMJ84_12395) 2599763..2600155 + 393 WP_227274803.1 hypothetical protein -
PMJ84_RS12400 (PMJ84_12400) 2600139..2600411 + 273 WP_227274804.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2581389..2646168 64779


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-71)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10824.61 Da        Isoelectric Point: 10.6249

>T269173 WP_025297453.1 NZ_CP116720:2595873-2596154 [Pseudomonas aeruginosa]
MTYELEFLPSALKEWQKLGHTVREQIKKKLRERLDNPKVQADALRDMPGHYKIKLRASGYRLVYRVEDERVVVVVVAVGK
RERGAAYQSAKGR

Download         Length: 282 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8797.21 Da        Isoelectric Point: 4.2550

>AT269173 WP_025297454.1 NZ_CP116720:2595638-2595883 [Pseudomonas aeruginosa]
MQSILADVAVSVSELKKNPSGILAGAGGMPVAVLNHNRVMGYMVPAELYEQMMERLDDLELVEIVKARSGEESVPVRLDD
L

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R8UIH5

Antitoxin

Source ID Structure
AlphaFold DB A0A3R8UIM7

References