Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | /Acetyltransf_4(toxin) |
Location | 5336482..5337990 | Replicon | chromosome |
Accession | NZ_CP116718 | ||
Organism | Pseudomonas aeruginosa strain 2858 |
Toxin (Protein)
Gene name | - | Uniprot ID | Q9HYX1 |
Locus tag | PMJ85_RS25260 | Protein ID | WP_003119682.1 |
Coordinates | 5337403..5337990 (-) | Length | 196 a.a. |
Antitoxin (Protein)
Gene name | - | Uniprot ID | A6V2F0 |
Locus tag | PMJ85_RS25255 | Protein ID | WP_012074952.1 |
Coordinates | 5336482..5337336 (-) | Length | 285 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
PMJ85_RS25240 (PMJ85_25240) | 5331902..5332111 | + | 210 | WP_003115568.1 | cold-shock protein | - |
PMJ85_RS25245 (PMJ85_25245) | 5332172..5334046 | - | 1875 | WP_003117607.1 | MFS transporter | - |
PMJ85_RS25250 (PMJ85_25250) | 5334221..5336386 | - | 2166 | WP_025297505.1 | TonB-dependent receptor family protein | - |
PMJ85_RS25255 (PMJ85_25255) | 5336482..5337336 | - | 855 | WP_012074952.1 | AraC family transcriptional regulator | Antitoxin |
PMJ85_RS25260 (PMJ85_25260) | 5337403..5337990 | - | 588 | WP_003119682.1 | GNAT family protein | Toxin |
PMJ85_RS25265 (PMJ85_25265) | 5338256..5341735 | + | 3480 | WP_003117605.1 | PAS domain-containing hybrid sensor histidine kinase/response regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 196 a.a. Molecular weight: 21901.23 Da Isoelectric Point: 9.8676
>T269169 WP_003119682.1 NZ_CP116718:c5337990-5337403 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG
Download Length: 588 bp
Antitoxin
Download Length: 285 a.a. Molecular weight: 31788.11 Da Isoelectric Point: 7.7066
>AT269169 WP_012074952.1 NZ_CP116718:c5337336-5336482 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSGFALVFIEQGAQRFRHRGGEHLAPWGSMVLINPDEVHTGSK
AHDSGWLYRGYYPEVEQIASILDELEIRHGGVPRFADSVVHDQPLARAFVHLHRLLADHAGSLETQTCWRETLLALFRRH
ARLPEAPKAGSEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKNGRA
PLDVALELGFADQSHLGRQFKQAYGVAPGEYRAACARSSLTMCE
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSGFALVFIEQGAQRFRHRGGEHLAPWGSMVLINPDEVHTGSK
AHDSGWLYRGYYPEVEQIASILDELEIRHGGVPRFADSVVHDQPLARAFVHLHRLLADHAGSLETQTCWRETLLALFRRH
ARLPEAPKAGSEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKNGRA
PLDVALELGFADQSHLGRQFKQAYGVAPGEYRAACARSSLTMCE
Download Length: 855 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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