Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/- |
Location | 4581321..4582542 | Replicon | chromosome |
Accession | NZ_CP116718 | ||
Organism | Pseudomonas aeruginosa strain 2858 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | A0A0H2Z8V4 |
Locus tag | PMJ85_RS21580 | Protein ID | WP_003110488.1 |
Coordinates | 4581964..4582542 (+) | Length | 193 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | - |
Locus tag | PMJ85_RS21575 | Protein ID | WP_003088112.1 |
Coordinates | 4581321..4581875 (+) | Length | 185 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
PMJ85_RS21550 (PMJ85_21550) | 4576889..4577440 | + | 552 | WP_003450159.1 | XRE family transcriptional regulator | - |
PMJ85_RS21555 (PMJ85_21555) | 4577437..4577835 | - | 399 | WP_003088123.1 | NADH-quinone oxidoreductase subunit A | - |
PMJ85_RS21560 (PMJ85_21560) | 4577848..4578171 | - | 324 | WP_015648646.1 | multidrug efflux SMR transporter | - |
PMJ85_RS21565 (PMJ85_21565) | 4578502..4578963 | + | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
PMJ85_RS21570 (PMJ85_21570) | 4578968..4581163 | + | 2196 | WP_003122807.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
PMJ85_RS21575 (PMJ85_21575) | 4581321..4581875 | + | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
PMJ85_RS21580 (PMJ85_21580) | 4581964..4582542 | + | 579 | WP_003110488.1 | HD domain-containing protein | Toxin |
PMJ85_RS21585 (PMJ85_21585) | 4582651..4583838 | - | 1188 | WP_003102741.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
PMJ85_RS21590 (PMJ85_21590) | 4583828..4585999 | - | 2172 | WP_025297367.1 | type I secretion system permease/ATPase | - |
PMJ85_RS21595 (PMJ85_21595) | 4585989..4587266 | - | 1278 | WP_003102743.1 | TolC family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21913.75 Da Isoelectric Point: 5.3655
>T269168 WP_003110488.1 NZ_CP116718:4581964-4582542 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT269168 WP_003088112.1 NZ_CP116718:4581321-4581875 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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