Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 4581321..4582542 Replicon chromosome
Accession NZ_CP116718
Organism Pseudomonas aeruginosa strain 2858

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag PMJ85_RS21580 Protein ID WP_003110488.1
Coordinates 4581964..4582542 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PMJ85_RS21575 Protein ID WP_003088112.1
Coordinates 4581321..4581875 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMJ85_RS21550 (PMJ85_21550) 4576889..4577440 + 552 WP_003450159.1 XRE family transcriptional regulator -
PMJ85_RS21555 (PMJ85_21555) 4577437..4577835 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
PMJ85_RS21560 (PMJ85_21560) 4577848..4578171 - 324 WP_015648646.1 multidrug efflux SMR transporter -
PMJ85_RS21565 (PMJ85_21565) 4578502..4578963 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
PMJ85_RS21570 (PMJ85_21570) 4578968..4581163 + 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PMJ85_RS21575 (PMJ85_21575) 4581321..4581875 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
PMJ85_RS21580 (PMJ85_21580) 4581964..4582542 + 579 WP_003110488.1 HD domain-containing protein Toxin
PMJ85_RS21585 (PMJ85_21585) 4582651..4583838 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
PMJ85_RS21590 (PMJ85_21590) 4583828..4585999 - 2172 WP_025297367.1 type I secretion system permease/ATPase -
PMJ85_RS21595 (PMJ85_21595) 4585989..4587266 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T269168 WP_003110488.1 NZ_CP116718:4581964-4582542 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT269168 WP_003088112.1 NZ_CP116718:4581321-4581875 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References