269167

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 3543816..3544858 Replicon chromosome
Accession NZ_CP116718
Organism Pseudomonas aeruginosa strain 2858

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag PMJ85_RS16935 Protein ID WP_003153636.1
Coordinates 3544283..3544858 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag PMJ85_RS16930 Protein ID WP_003050245.1
Coordinates 3543816..3544286 (+) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMJ85_RS16895 (PMJ85_16895) 3539208..3540626 - 1419 WP_006226029.1 TIGR03752 family integrating conjugative element protein -
PMJ85_RS16900 (PMJ85_16900) 3540616..3541527 - 912 WP_006226028.1 TIGR03749 family integrating conjugative element protein -
PMJ85_RS16905 (PMJ85_16905) 3541524..3542216 - 693 WP_003090182.1 TIGR03746 family integrating conjugative element protein -
PMJ85_RS16910 (PMJ85_16910) 3542213..3542611 - 399 WP_003050133.1 TIGR03750 family conjugal transfer protein -
PMJ85_RS16915 (PMJ85_16915) 3542623..3542982 - 360 WP_003090173.1 TIGR03745 family integrating conjugative element membrane protein -
PMJ85_RS16920 (PMJ85_16920) 3542999..3543232 - 234 WP_023101201.1 TIGR03758 family integrating conjugative element protein -
PMJ85_RS16925 (PMJ85_16925) 3543229..3543612 - 384 WP_003090167.1 RAQPRD family integrative conjugative element protein -
PMJ85_RS16930 (PMJ85_16930) 3543816..3544286 + 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
PMJ85_RS16935 (PMJ85_16935) 3544283..3544858 + 576 WP_003153636.1 PIN domain-containing protein Toxin
PMJ85_RS16940 (PMJ85_16940) 3544876..3545790 + 915 WP_016852809.1 AAA family ATPase -
PMJ85_RS16945 (PMJ85_16945) 3545787..3546257 + 471 WP_003090160.1 type III CBASS phage resistance system CD-NTase-associated protein Cap8 -
PMJ85_RS16950 (PMJ85_16950) 3546254..3546754 + 501 WP_003090159.1 type III CBASS phage resistance system CD-NTase-associated protein Cap7 -
PMJ85_RS16955 (PMJ85_16955) 3546754..3547656 + 903 WP_003090158.1 CBASS oligonucleotide cyclase -
PMJ85_RS16960 (PMJ85_16960) 3547695..3548420 + 726 WP_003050273.1 CBASS effector endonuclease NucC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21629.78 Da        Isoelectric Point: 5.9995

>T269167 WP_003153636.1 NZ_CP116718:3544283-3544858 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT269167 WP_003050245.1 NZ_CP116718:3543816-3544286 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References