Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 3248981..3249497 Replicon chromosome
Accession NZ_CP116718
Organism Pseudomonas aeruginosa strain 2858

Toxin (Protein)


Gene name relE Uniprot ID A0A3R8UIH5
Locus tag PMJ85_RS15605 Protein ID WP_025297453.1
Coordinates 3249216..3249497 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3R8UIM7
Locus tag PMJ85_RS15600 Protein ID WP_025297454.1
Coordinates 3248981..3249226 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMJ85_RS15580 (PMJ85_15580) 3244103..3244432 - 330 WP_031692728.1 hypothetical protein -
PMJ85_RS15585 (PMJ85_15585) 3244780..3245448 + 669 WP_071534660.1 hypothetical protein -
PMJ85_RS15590 (PMJ85_15590) 3245445..3246551 + 1107 WP_025297456.1 XRE family transcriptional regulator -
PMJ85_RS15595 (PMJ85_15595) 3246682..3248823 + 2142 WP_025297455.1 hypothetical protein -
PMJ85_RS15600 (PMJ85_15600) 3248981..3249226 + 246 WP_025297454.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
PMJ85_RS15605 (PMJ85_15605) 3249216..3249497 + 282 WP_025297453.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PMJ85_RS15610 (PMJ85_15610) 3249903..3250484 - 582 WP_033895412.1 plasmid pRiA4b ORF-3 family protein -
PMJ85_RS15615 (PMJ85_15615) 3250498..3251373 - 876 WP_033895413.1 WYL domain-containing protein -
PMJ85_RS15620 (PMJ85_15620) 3251502..3253082 + 1581 WP_063837559.1 DNA recombination protein RmuC -
PMJ85_RS15625 (PMJ85_15625) 3253106..3253498 + 393 WP_227274803.1 hypothetical protein -
PMJ85_RS15630 (PMJ85_15630) 3253482..3253754 + 273 WP_227274804.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3234732..3301879 67147


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-71)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10824.61 Da        Isoelectric Point: 10.6249

>T269166 WP_025297453.1 NZ_CP116718:3249216-3249497 [Pseudomonas aeruginosa]
MTYELEFLPSALKEWQKLGHTVREQIKKKLRERLDNPKVQADALRDMPGHYKIKLRASGYRLVYRVEDERVVVVVVAVGK
RERGAAYQSAKGR

Download         Length: 282 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8797.21 Da        Isoelectric Point: 4.2550

>AT269166 WP_025297454.1 NZ_CP116718:3248981-3249226 [Pseudomonas aeruginosa]
MQSILADVAVSVSELKKNPSGILAGAGGMPVAVLNHNRVMGYMVPAELYEQMMERLDDLELVEIVKARSGEESVPVRLDD
L

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R8UIH5

Antitoxin

Source ID Structure
AlphaFold DB A0A3R8UIM7

References