269165

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 2450882..2452140 Replicon chromosome
Accession NZ_CP116718
Organism Pseudomonas aeruginosa strain 2858

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag PMJ85_RS11670 Protein ID WP_003086331.1
Coordinates 2451385..2452140 (+) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PMJ85_RS11665 Protein ID WP_003086329.1
Coordinates 2450882..2451250 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMJ85_RS11645 (PMJ85_11645) 2447045..2447320 + 276 WP_023088486.1 zinc ribbon domain-containing protein -
PMJ85_RS11650 (PMJ85_11650) 2447323..2447799 - 477 WP_004353334.1 elongation factor GreAB -
PMJ85_RS11655 (PMJ85_11655) 2447878..2449467 + 1590 WP_023464367.1 aldehyde dehydrogenase family protein -
PMJ85_RS11660 (PMJ85_11660) 2449523..2450809 + 1287 WP_003086327.1 FAD-binding oxidoreductase -
PMJ85_RS11665 (PMJ85_11665) 2450882..2451250 + 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PMJ85_RS11670 (PMJ85_11670) 2451385..2452140 + 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
PMJ85_RS11675 (PMJ85_11675) 2452909..2454270 + 1362 WP_003120632.1 DNA recombination protein RmuC -
PMJ85_RS11680 (PMJ85_11680) 2454426..2456969 - 2544 WP_033955245.1 acyl-homoserine-lactone acylase QuiP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T269165 WP_003086331.1 NZ_CP116718:2451385-2452140 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT269165 WP_003086329.1 NZ_CP116718:2450882-2451250 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References