Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 4120155..4121376 Replicon chromosome
Accession NZ_CP116717
Organism Pseudomonas aeruginosa strain 2857

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag PMJ94_RS19505 Protein ID WP_003110488.1
Coordinates 4120798..4121376 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PMJ94_RS19500 Protein ID WP_003088112.1
Coordinates 4120155..4120709 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMJ94_RS19475 (PMJ94_19475) 4115723..4116274 + 552 WP_003450159.1 XRE family transcriptional regulator -
PMJ94_RS19480 (PMJ94_19480) 4116271..4116669 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
PMJ94_RS19485 (PMJ94_19485) 4116682..4117005 - 324 WP_015648646.1 multidrug efflux SMR transporter -
PMJ94_RS19490 (PMJ94_19490) 4117336..4117797 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
PMJ94_RS19495 (PMJ94_19495) 4117802..4119997 + 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PMJ94_RS19500 (PMJ94_19500) 4120155..4120709 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
PMJ94_RS19505 (PMJ94_19505) 4120798..4121376 + 579 WP_003110488.1 HD domain-containing protein Toxin
PMJ94_RS19510 (PMJ94_19510) 4121485..4122672 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
PMJ94_RS19515 (PMJ94_19515) 4122662..4124833 - 2172 WP_025297367.1 type I secretion system permease/ATPase -
PMJ94_RS19520 (PMJ94_19520) 4124823..4126100 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T269160 WP_003110488.1 NZ_CP116717:4120798-4121376 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT269160 WP_003088112.1 NZ_CP116717:4120155-4120709 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References