Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2872546..2873062 Replicon chromosome
Accession NZ_CP116717
Organism Pseudomonas aeruginosa strain 2857

Toxin (Protein)


Gene name relE Uniprot ID A0A3R8UIH5
Locus tag PMJ94_RS14015 Protein ID WP_025297453.1
Coordinates 2872781..2873062 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3R8UIM7
Locus tag PMJ94_RS14010 Protein ID WP_025297454.1
Coordinates 2872546..2872791 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMJ94_RS13990 (PMJ94_13990) 2867668..2867997 - 330 WP_031692728.1 hypothetical protein -
PMJ94_RS13995 (PMJ94_13995) 2868345..2869013 + 669 WP_071534660.1 hypothetical protein -
PMJ94_RS14000 (PMJ94_14000) 2869010..2870116 + 1107 WP_025297456.1 XRE family transcriptional regulator -
PMJ94_RS14005 (PMJ94_14005) 2870247..2872388 + 2142 WP_025297455.1 hypothetical protein -
PMJ94_RS14010 (PMJ94_14010) 2872546..2872791 + 246 WP_025297454.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
PMJ94_RS14015 (PMJ94_14015) 2872781..2873062 + 282 WP_025297453.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PMJ94_RS14020 (PMJ94_14020) 2873468..2874049 - 582 WP_033895412.1 plasmid pRiA4b ORF-3 family protein -
PMJ94_RS14025 (PMJ94_14025) 2874063..2874938 - 876 WP_033895413.1 WYL domain-containing protein -
PMJ94_RS14030 (PMJ94_14030) 2875067..2876647 + 1581 WP_063837559.1 DNA recombination protein RmuC -
PMJ94_RS14035 (PMJ94_14035) 2876671..2877063 + 393 WP_227274803.1 hypothetical protein -
PMJ94_RS14040 (PMJ94_14040) 2877047..2877319 + 273 WP_227274804.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2855781..2923505 67724


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-71)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10824.61 Da        Isoelectric Point: 10.6249

>T269159 WP_025297453.1 NZ_CP116717:2872781-2873062 [Pseudomonas aeruginosa]
MTYELEFLPSALKEWQKLGHTVREQIKKKLRERLDNPKVQADALRDMPGHYKIKLRASGYRLVYRVEDERVVVVVVAVGK
RERGAAYQSAKGR

Download         Length: 282 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8797.21 Da        Isoelectric Point: 4.2550

>AT269159 WP_025297454.1 NZ_CP116717:2872546-2872791 [Pseudomonas aeruginosa]
MQSILADVAVSVSELKKNPSGILAGAGGMPVAVLNHNRVMGYMVPAELYEQMMERLDDLELVEIVKARSGEESVPVRLDD
L

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R8UIH5

Antitoxin

Source ID Structure
AlphaFold DB A0A3R8UIM7

References