269158

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 2731178..2732220 Replicon chromosome
Accession NZ_CP116717
Organism Pseudomonas aeruginosa strain 2857

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag PMJ94_RS13170 Protein ID WP_003153636.1
Coordinates 2731645..2732220 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag PMJ94_RS13165 Protein ID WP_003050245.1
Coordinates 2731178..2731648 (+) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMJ94_RS13130 (PMJ94_13130) 2726570..2727988 - 1419 WP_006226029.1 TIGR03752 family integrating conjugative element protein -
PMJ94_RS13135 (PMJ94_13135) 2727978..2728889 - 912 WP_006226028.1 TIGR03749 family integrating conjugative element protein -
PMJ94_RS13140 (PMJ94_13140) 2728886..2729578 - 693 WP_003090182.1 TIGR03746 family integrating conjugative element protein -
PMJ94_RS13145 (PMJ94_13145) 2729575..2729973 - 399 WP_003050133.1 TIGR03750 family conjugal transfer protein -
PMJ94_RS13150 (PMJ94_13150) 2729985..2730344 - 360 WP_003090173.1 TIGR03745 family integrating conjugative element membrane protein -
PMJ94_RS13155 (PMJ94_13155) 2730361..2730594 - 234 WP_023101201.1 TIGR03758 family integrating conjugative element protein -
PMJ94_RS13160 (PMJ94_13160) 2730591..2730974 - 384 WP_003090167.1 RAQPRD family integrative conjugative element protein -
PMJ94_RS13165 (PMJ94_13165) 2731178..2731648 + 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
PMJ94_RS13170 (PMJ94_13170) 2731645..2732220 + 576 WP_003153636.1 PIN domain-containing protein Toxin
PMJ94_RS13175 (PMJ94_13175) 2732238..2733152 + 915 WP_016852809.1 AAA family ATPase -
PMJ94_RS13180 (PMJ94_13180) 2733149..2733619 + 471 WP_003090160.1 type III CBASS phage resistance system CD-NTase-associated protein Cap8 -
PMJ94_RS13185 (PMJ94_13185) 2733616..2734116 + 501 WP_003090159.1 type III CBASS phage resistance system CD-NTase-associated protein Cap7 -
PMJ94_RS13190 (PMJ94_13190) 2734116..2735018 + 903 WP_003090158.1 CBASS oligonucleotide cyclase -
PMJ94_RS13195 (PMJ94_13195) 2735057..2735782 + 726 WP_003050273.1 CBASS effector endonuclease NucC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2654241..2777712 123471


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21629.78 Da        Isoelectric Point: 5.9995

>T269158 WP_003153636.1 NZ_CP116717:2731645-2732220 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT269158 WP_003050245.1 NZ_CP116717:2731178-2731648 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References