Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3931852..3933073 Replicon chromosome
Accession NZ_CP116715
Organism Pseudomonas aeruginosa strain 2856

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag PMJ91_RS18690 Protein ID WP_003110488.1
Coordinates 3932495..3933073 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PMJ91_RS18685 Protein ID WP_003088112.1
Coordinates 3931852..3932406 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMJ91_RS18660 (PMJ91_18660) 3927420..3927971 + 552 WP_003450159.1 XRE family transcriptional regulator -
PMJ91_RS18665 (PMJ91_18665) 3927968..3928366 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
PMJ91_RS18670 (PMJ91_18670) 3928379..3928702 - 324 WP_015648646.1 multidrug efflux SMR transporter -
PMJ91_RS18675 (PMJ91_18675) 3929033..3929494 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
PMJ91_RS18680 (PMJ91_18680) 3929499..3931694 + 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PMJ91_RS18685 (PMJ91_18685) 3931852..3932406 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
PMJ91_RS18690 (PMJ91_18690) 3932495..3933073 + 579 WP_003110488.1 HD domain-containing protein Toxin
PMJ91_RS18695 (PMJ91_18695) 3933182..3934369 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
PMJ91_RS18700 (PMJ91_18700) 3934359..3936530 - 2172 WP_025297367.1 type I secretion system permease/ATPase -
PMJ91_RS18705 (PMJ91_18705) 3936520..3937797 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T269152 WP_003110488.1 NZ_CP116715:3932495-3933073 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT269152 WP_003088112.1 NZ_CP116715:3931852-3932406 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References