Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 2828363..2829405 Replicon chromosome
Accession NZ_CP116715
Organism Pseudomonas aeruginosa strain 2856

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag PMJ91_RS13605 Protein ID WP_003153636.1
Coordinates 2828830..2829405 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag PMJ91_RS13600 Protein ID WP_003050245.1
Coordinates 2828363..2828833 (+) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMJ91_RS13565 (PMJ91_13565) 2823755..2825173 - 1419 WP_006226029.1 TIGR03752 family integrating conjugative element protein -
PMJ91_RS13570 (PMJ91_13570) 2825163..2826074 - 912 WP_006226028.1 TIGR03749 family integrating conjugative element protein -
PMJ91_RS13575 (PMJ91_13575) 2826071..2826763 - 693 WP_003090182.1 TIGR03746 family integrating conjugative element protein -
PMJ91_RS13580 (PMJ91_13580) 2826760..2827158 - 399 WP_003050133.1 TIGR03750 family conjugal transfer protein -
PMJ91_RS13585 (PMJ91_13585) 2827170..2827529 - 360 WP_003090173.1 TIGR03745 family integrating conjugative element membrane protein -
PMJ91_RS13590 (PMJ91_13590) 2827546..2827779 - 234 WP_023101201.1 TIGR03758 family integrating conjugative element protein -
PMJ91_RS13595 (PMJ91_13595) 2827776..2828159 - 384 WP_003090167.1 RAQPRD family integrative conjugative element protein -
PMJ91_RS13600 (PMJ91_13600) 2828363..2828833 + 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
PMJ91_RS13605 (PMJ91_13605) 2828830..2829405 + 576 WP_003153636.1 PIN domain-containing protein Toxin
PMJ91_RS13610 (PMJ91_13610) 2829423..2830337 + 915 WP_016852809.1 AAA family ATPase -
PMJ91_RS13615 (PMJ91_13615) 2830334..2830804 + 471 WP_003090160.1 type III CBASS phage resistance system CD-NTase-associated protein Cap8 -
PMJ91_RS13620 (PMJ91_13620) 2830801..2831301 + 501 WP_003090159.1 type III CBASS phage resistance system CD-NTase-associated protein Cap7 -
PMJ91_RS13625 (PMJ91_13625) 2831301..2832203 + 903 WP_003090158.1 CBASS oligonucleotide cyclase -
PMJ91_RS13630 (PMJ91_13630) 2832242..2832967 + 726 WP_003050273.1 CBASS effector endonuclease NucC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21629.78 Da        Isoelectric Point: 5.9995

>T269151 WP_003153636.1 NZ_CP116715:2828830-2829405 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT269151 WP_003050245.1 NZ_CP116715:2828363-2828833 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References