Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2662328..2662844 Replicon chromosome
Accession NZ_CP116715
Organism Pseudomonas aeruginosa strain 2856

Toxin (Protein)


Gene name relE Uniprot ID A0A3R8UIH5
Locus tag PMJ91_RS12795 Protein ID WP_025297453.1
Coordinates 2662563..2662844 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3R8UIM7
Locus tag PMJ91_RS12790 Protein ID WP_025297454.1
Coordinates 2662328..2662573 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMJ91_RS12770 (PMJ91_12770) 2657450..2657779 - 330 WP_031692728.1 hypothetical protein -
PMJ91_RS12775 (PMJ91_12775) 2658127..2658795 + 669 WP_071534660.1 hypothetical protein -
PMJ91_RS12780 (PMJ91_12780) 2658792..2659898 + 1107 WP_025297456.1 XRE family transcriptional regulator -
PMJ91_RS12785 (PMJ91_12785) 2660029..2662170 + 2142 WP_025297455.1 hypothetical protein -
PMJ91_RS12790 (PMJ91_12790) 2662328..2662573 + 246 WP_025297454.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
PMJ91_RS12795 (PMJ91_12795) 2662563..2662844 + 282 WP_025297453.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PMJ91_RS12800 (PMJ91_12800) 2663250..2663831 - 582 WP_033895412.1 plasmid pRiA4b ORF-3 family protein -
PMJ91_RS12805 (PMJ91_12805) 2663845..2664720 - 876 WP_033895413.1 WYL domain-containing protein -
PMJ91_RS12810 (PMJ91_12810) 2664849..2666429 + 1581 WP_063837559.1 DNA recombination protein RmuC -
PMJ91_RS12815 (PMJ91_12815) 2666453..2666845 + 393 WP_227274803.1 hypothetical protein -
PMJ91_RS12820 (PMJ91_12820) 2666829..2667101 + 273 WP_227274804.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2648079..2669082 21003


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-71)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10824.61 Da        Isoelectric Point: 10.6249

>T269150 WP_025297453.1 NZ_CP116715:2662563-2662844 [Pseudomonas aeruginosa]
MTYELEFLPSALKEWQKLGHTVREQIKKKLRERLDNPKVQADALRDMPGHYKIKLRASGYRLVYRVEDERVVVVVVAVGK
RERGAAYQSAKGR

Download         Length: 282 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8797.21 Da        Isoelectric Point: 4.2550

>AT269150 WP_025297454.1 NZ_CP116715:2662328-2662573 [Pseudomonas aeruginosa]
MQSILADVAVSVSELKKNPSGILAGAGGMPVAVLNHNRVMGYMVPAELYEQMMERLDDLELVEIVKARSGEESVPVRLDD
L

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R8UIH5

Antitoxin

Source ID Structure
AlphaFold DB A0A3R8UIM7

References