Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2226303..2227201 Replicon chromosome
Accession NC_017524
Organism Mycobacterium tuberculosis CTRI-2

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag MTCTRI2_RS10415 Protein ID WP_003410001.1
Coordinates 2226303..2226863 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag MTCTRI2_RS10420 Protein ID WP_003410003.1
Coordinates 2226860..2227201 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTCTRI2_RS10385 2221472..2222125 - 654 WP_003409976.1 cutinase Cfp21 -
MTCTRI2_RS10390 2222240..2222470 + 231 WP_003409980.1 DUF167 domain-containing protein -
MTCTRI2_RS10395 2222555..2223466 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
MTCTRI2_RS10400 2223575..2224174 + 600 WP_003409989.1 L-lysine exporter -
MTCTRI2_RS10405 2224590..2225018 + 429 WP_003906713.1 cellulose-binding protein -
MTCTRI2_RS10410 2225244..2225783 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
MTCTRI2_RS10415 2226303..2226863 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
MTCTRI2_RS10420 2226860..2227201 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
MTCTRI2_RS10425 2227287..2227544 + 258 WP_003410006.1 hypothetical protein -
MTCTRI2_RS10430 2227445..2227780 - 336 WP_003410009.1 dehydrogenase -
MTCTRI2_RS10435 2227869..2228213 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
MTCTRI2_RS10440 2228207..2228455 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
MTCTRI2_RS10445 2228555..2230870 - 2316 WP_003899120.1 cation transporter ATPase CptG -
MTCTRI2_RS10450 2230867..2231139 - 273 WP_003410017.1 DUF1490 family protein -
MTCTRI2_RS10455 2231192..2231548 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T26915 WP_003410001.1 NC_017524:c2226863-2226303 [Mycobacterium tuberculosis CTRI-2]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T26915 NC_017524:c2226863-2226303 [Mycobacterium tuberculosis CTRI-2]
GTGAGCGATGCCCTCGATGAAGGGCTCGTCCAGCGTATCGACGCACGCGGAACAATTGAGTGGTCGGAAACGTGCTACCG
GTATACCGGCGCGCACCGTGACGCCTTGTCCGGTGAGGGCGCGCGCAGATTCGGAGGCAGGTGGAATCCGCCGCTGCTCT
TTCCGGCGATCTATCTTGCTGATTCCGCCCAAGCCTGCATGGTTGAGGTGGAACGGGCGGCGCAAGCGGCTTCAACGACC
GCAGAGAAGATGCTCGAGGCGGCCTACCGACTACACACGATCGACGTCACGGACCTGGCCGTCCTCGATCTGACAACCCC
GCAAGCTCGGGAAGCCGTGGGGCTCGAGAACGACGACATCTATGGCGACGACTGGTCAGGGTGCCAGGCGGTCGGACATG
CGGCCTGGTTCTTGCACATGCAAGGTGTCCTCGTGCCGGCGGCGGGCGGTGTCGGCCTCGTTGTCACCGCGTATGAACAG
CGAACTCGGCCGGGCCAACTACAACTGCGACAAAGCGTCGATCTGACGCCTGCTCTTTACCAAGAACTTCGAGCCACGTA
G

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT26915 WP_003410003.1 NC_017524:c2227201-2226860 [Mycobacterium tuberculosis CTRI-2]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT26915 NC_017524:c2227201-2226860 [Mycobacterium tuberculosis CTRI-2]
ATGGGAGTAAATGTGCTCGCCTCGACCGTGTCGGGTGCGATCGAGCGCTTGGGATTGACCTACGAGGAAGTCGGTGACAT
CGTCGATGCCTCGCCGCGTTCCGTGGCGCGATGGACCGCAGGTCAGGTGGTTCCCCAACGCCTCAACAAGCAACGACTTA
TCGAGCTGGCCTATGTCGCCGACGCCCTCGCGGAAGTGCTGCCGCGTGACCAGGCGAACGTGTGGATGTTTTCGCCGAAT
CGGTTACTGGAACACCGCAAGCCTGCCGACCTCGTGCGAGACGGCGAGTACCAACGCGTGTTGGCGCTCATCGACGCGAT
GGCGGAGGGAGTGTTCGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References