Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 249138..249750 Replicon chromosome
Accession NZ_CP116706
Organism Streptococcus agalactiae strain A909 sCas9

Toxin (Protein)


Gene name parE Uniprot ID A0A8G2N8L3
Locus tag POF65_RS01445 Protein ID WP_000384860.1
Coordinates 249138..249473 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q8E7D2
Locus tag POF65_RS01450 Protein ID WP_000259017.1
Coordinates 249463..249750 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
POF65_RS01420 (POF65_01420) 244336..244977 + 642 WP_000591144.1 hypothetical protein -
POF65_RS01425 (POF65_01425) 245277..246152 + 876 WP_000421240.1 hypothetical protein -
POF65_RS01430 (POF65_01430) 246188..246622 + 435 WP_001220479.1 hypothetical protein -
POF65_RS01435 (POF65_01435) 246939..248195 + 1257 WP_000122836.1 MobV family relaxase -
POF65_RS01440 (POF65_01440) 248363..248833 + 471 WP_000130119.1 hypothetical protein -
POF65_RS01445 (POF65_01445) 249138..249473 - 336 WP_000384860.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
POF65_RS01450 (POF65_01450) 249463..249750 - 288 WP_000259017.1 hypothetical protein Antitoxin
POF65_RS01455 (POF65_01455) 250257..250547 + 291 WP_000078283.1 WXG100 family type VII secretion target -
POF65_RS01460 (POF65_01460) 250649..251056 + 408 WP_000749954.1 hypothetical protein -
POF65_RS01465 (POF65_01465) 251056..251616 + 561 WP_001865562.1 hypothetical protein -
POF65_RS01470 (POF65_01470) 251589..252269 + 681 WP_001865565.1 hypothetical protein -
POF65_RS01475 (POF65_01475) 252254..252640 + 387 WP_000259069.1 hypothetical protein -
POF65_RS01480 (POF65_01480) 252674..252955 + 282 WP_000052406.1 hypothetical protein -
POF65_RS01485 (POF65_01485) 253798..254658 + 861 WP_000477654.1 Rgg/GadR/MutR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13227.87 Da        Isoelectric Point: 4.5348

>T269143 WP_000384860.1 NZ_CP116706:c249473-249138 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENSVVIDYLLPTRSDYMKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10906.50 Da        Isoelectric Point: 4.7271

>AT269143 WP_000259017.1 NZ_CP116706:c249750-249463 [Streptococcus agalactiae]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A076Z4V6

References