Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2099696..2101206 Replicon chromosome
Accession NZ_CP116701
Organism Agrobacterium fabacearum strain A47a

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag G6M09_RS22635 Protein ID WP_174073204.1
Coordinates 2099965..2101206 (+) Length 414 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag G6M09_RS22630 Protein ID WP_038495687.1
Coordinates 2099696..2099968 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6M09_RS22590 (G6M09_022590) 2095169..2095714 + 546 WP_113292384.1 sugar ABC transporter -
G6M09_RS22595 (G6M09_022595) 2095720..2096046 + 327 WP_113292383.1 hypothetical protein -
G6M09_RS22600 (G6M09_022600) 2096067..2096906 + 840 WP_113292382.1 MBL fold metallo-hydrolase -
G6M09_RS22605 (G6M09_022605) 2096967..2097350 - 384 WP_111801661.1 ester cyclase -
G6M09_RS22610 (G6M09_022610) 2097421..2098041 - 621 WP_113292381.1 histidine phosphatase family protein -
G6M09_RS22615 (G6M09_022615) 2098019..2098588 - 570 WP_113292380.1 AAA family ATPase -
G6M09_RS22620 (G6M09_022620) 2098701..2098829 - 129 WP_272434428.1 hypothetical protein -
G6M09_RS22625 (G6M09_022625) 2098953..2099273 - 321 WP_113292379.1 hypothetical protein -
G6M09_RS22630 (G6M09_022630) 2099696..2099968 + 273 WP_038495687.1 helix-turn-helix domain-containing protein Antitoxin
G6M09_RS22635 (G6M09_022635) 2099965..2101206 + 1242 WP_174073204.1 type II toxin-antitoxin system HipA family toxin Toxin
G6M09_RS22640 (G6M09_022640) 2101588..2102007 + 420 WP_174073206.1 thermonuclease family protein -
G6M09_RS22645 (G6M09_022645) 2102220..2102597 + 378 WP_112162396.1 hypothetical protein -
G6M09_RS22650 (G6M09_022650) 2104761..2105855 + 1095 WP_113292376.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(137-368)

Antitoxin

Cro/C1-type helix-turn-helix domain

(9-66)


Sequences

Toxin        


Download         Length: 414 a.a.        Molecular weight: 45366.25 Da        Isoelectric Point: 7.9341

>T269138 WP_174073204.1 NZ_CP116701:2099965-2101206 [Agrobacterium fabacearum]
MTTIYYETLPVAHLTFEGEWRLDYDPGWEARRPAFPVSLTMPLRSGFVGAAKLLPWLANLLPETHLAEIGQRLKVSPQDI
VGLLAHIGRDTAGALSIGEPRKAGVNLRPVPDEQALERILNELPAKPFLVGERGVSMSLAGVQEKLPVFADGNGRISVPV
DGMPSTHILKPDTKRLAGSVENEAFCLSLARACGLDAAEATIGVAGKRRYLLVKRYDRFTDAQGEIRRLHQEDLCQLTGY
FPSQKYERSSTGPGVTMKMMFDAVSNLVSPGERLKLLDAVIFNVLICNSDSHAKNYSILIGAGGSAKMAPLYDLMCAAVY
RRVDQSLPQGISGRFHAPDVRRADWQALADDIGLSGASTLKRVEELAKLVSVACDEVAPYIVALSSDPTRILERITHSVQ
KRCRRIQEQMHDR

Download         Length: 1242 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9695.11 Da        Isoelectric Point: 6.2834

>AT269138 WP_038495687.1 NZ_CP116701:2099696-2099968 [Agrobacterium fabacearum]
MFRSARDFGAAIKERRKALGWTQTGLAARSGTGERFIVELESGKPSCQLEKALIVARAVGIDLGDLKTVQTVQVAPDDDL
GFLPMFGADQ

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References