Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 167137..167927 Replicon plasmid pAtCG920
Accession NZ_CP116698
Organism Agrobacterium fabacearum strain CG920

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag G6L96_RS24820 Protein ID WP_174012795.1
Coordinates 167430..167927 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A1S7NER6
Locus tag G6L96_RS24815 Protein ID WP_019565754.1
Coordinates 167137..167433 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6L96_RS24795 (G6L96_024795) 162505..164229 + 1725 WP_174012794.1 ABC transporter ATP-binding protein -
G6L96_RS24800 (G6L96_024800) 164274..165461 + 1188 WP_065662740.1 galactarate dehydratase -
G6L96_RS24805 (G6L96_024805) 165448..166314 + 867 WP_025591536.1 aldose 1-epimerase -
G6L96_RS24810 (G6L96_024810) 166524..166954 + 431 Protein_163 DDE-type integrase/transposase/recombinase -
G6L96_RS24815 (G6L96_024815) 167137..167433 + 297 WP_019565754.1 DUF1778 domain-containing protein Antitoxin
G6L96_RS24820 (G6L96_024820) 167430..167927 + 498 WP_174012795.1 GNAT family N-acetyltransferase Toxin
G6L96_RS24825 (G6L96_024825) 168207..168872 - 666 WP_141194222.1 GNAT family N-acetyltransferase -
G6L96_RS24830 (G6L96_024830) 168838..169998 - 1161 WP_174012796.1 Gfo/Idh/MocA family oxidoreductase -
G6L96_RS24835 (G6L96_024835) 170030..171280 - 1251 WP_174012797.1 ROK family protein -
G6L96_RS24840 (G6L96_024840) 171493..172452 + 960 WP_174012798.1 extracellular solute-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..719769 719769


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-142)

Antitoxin

Vibrio phage ICP1, Orf50

(16-90)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 17739.30 Da        Isoelectric Point: 6.8629

>T269135 WP_174012795.1 NZ_CP116698:167430-167927 [Agrobacterium fabacearum]
VTLSAPIPLADHHELAEFNSGVPELDDWLRRRARANQAGGASRTFVVCDESRVIAYYALASGSVKPPEVPGRFRRNMPDP
IPVAVLGRLAIDQSCQGRGIGRALVRDAGLRLLNAAEVLGIRGVLVHAISDDARAFYEAVGFLSSPSDPMMLMVGLHDLN
NALNT

Download         Length: 498 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11022.59 Da        Isoelectric Point: 7.0159

>AT269135 WP_019565754.1 NZ_CP116698:167137-167433 [Agrobacterium fabacearum]
MPTSHTGKSPDASVPLNMRIKPATRNLIDRAAELLGKTRTDFMLEASERRAEEVLLDRTIVTVSPEIYAEYLARLDAPAQ
PNERLKRTMSTKAPWDEA

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1S7NER6

References