Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 9938..11448 Replicon chromosome
Accession NZ_CP116697
Organism Agrobacterium fabacearum strain CG920

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag G6L96_RS14255 Protein ID WP_174012598.1
Coordinates 9938..11179 (-) Length 414 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag G6L96_RS14260 Protein ID WP_097099301.1
Coordinates 11176..11448 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6L96_RS14220 (G6L96_014220) 5113..5558 + 446 Protein_7 transposase -
G6L96_RS14225 (G6L96_014225) 5662..5904 - 243 Protein_8 GNAT family N-acetyltransferase -
G6L96_RS14230 (G6L96_014230) 6281..6901 + 621 WP_174012615.1 hypothetical protein -
G6L96_RS14235 (G6L96_014235) 7456..7884 - 429 WP_236761616.1 hypothetical protein -
G6L96_RS14240 (G6L96_014240) 8225..8551 - 327 WP_174012602.1 hypothetical protein -
G6L96_RS14245 (G6L96_014245) 8548..8925 - 378 WP_112162396.1 hypothetical protein -
G6L96_RS14250 (G6L96_014250) 9138..9557 - 420 WP_174012600.1 thermonuclease family protein -
G6L96_RS14255 (G6L96_014255) 9938..11179 - 1242 WP_174012598.1 type II toxin-antitoxin system HipA family toxin Toxin
G6L96_RS14260 (G6L96_014260) 11176..11448 - 273 WP_097099301.1 helix-turn-helix domain-containing protein Antitoxin
G6L96_RS14265 (G6L96_014265) 11870..12190 + 321 WP_174012596.1 hypothetical protein -
G6L96_RS14270 (G6L96_014270) 12314..12442 + 129 WP_272448182.1 hypothetical protein -
G6L96_RS14275 (G6L96_014275) 12549..13316 - 768 WP_174002541.1 hypothetical protein -
G6L96_RS14280 (G6L96_014280) 13438..13683 + 246 WP_272448183.1 helix-turn-helix transcriptional regulator -
G6L96_RS14285 (G6L96_014285) 13816..14370 + 555 WP_174012592.1 AAA family ATPase -
G6L96_RS14290 (G6L96_014290) 14406..14990 + 585 WP_038495682.1 histidine phosphatase family protein -
G6L96_RS14295 (G6L96_014295) 15060..15454 + 395 Protein_22 ester cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(9-66)


Sequences

Toxin        


Download         Length: 414 a.a.        Molecular weight: 45467.25 Da        Isoelectric Point: 7.4104

>T269133 WP_174012598.1 NZ_CP116697:c11179-9938 [Agrobacterium fabacearum]
MTTIYYETLPVAHLSFEGEWRLDYDPGWEARRPAFPVSLTMPLRSGSVGAAKLLPWLANLLPETHLAEIGQRLKVSPQDI
VGLLAHIGRDTAGALSIGEPRKAGVNLQPVPDEQALERILNELPAKPFLVGERGVSMSLAGVQEKLPVFVEGSGRISVPV
DGTPSTHILKPDTKRLAGSVENEAFCLSLARACGLDAAEATIGVAGKRRYLLVKRYDRFTDAQGEIRRLHQEDLCQLTGY
FPSQKYERSSTGRGVTMKMMFDAVSDLVSPGERLKLLDAVIFNVLICNSDSHAKNYSILIGAGGSAKMAPLYDLMCAAVY
HQVDQSLPQEISGRFHAPDLRRADWQALADDIGLSGASTLKRVEELAKLVNVACDEVARYIVALSSDPTRILERITHSIQ
KRCRRIQEQMRDR

Download         Length: 1242 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9667.06 Da        Isoelectric Point: 6.2834

>AT269133 WP_097099301.1 NZ_CP116697:c11448-11176 [Agrobacterium fabacearum]
MFRSARDFGAAIKERRKALGWTQTGLAARSGTGERFIVELESGKPSCQLEKALIVARAVGIDLGDLKTVQTVQAAPDDDL
GFLPMFGADQ

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References