Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 539521..540067 Replicon chromosome
Accession NZ_CP116692
Organism Agrobacterium tumefaciens strain A74a

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag G6M15_RS02670 Protein ID WP_211398631.1
Coordinates 539801..540067 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag G6M15_RS02665 Protein ID WP_174007791.1
Coordinates 539521..539820 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6M15_RS02640 (G6M15_02640) 534657..535655 + 999 WP_174007778.1 asparaginase -
G6M15_RS02645 (G6M15_02645) 535794..536414 + 621 WP_174007780.1 glutathione S-transferase family protein -
G6M15_RS02650 (G6M15_02650) 536554..537213 - 660 WP_174007782.1 glutathione S-transferase family protein -
G6M15_RS02655 (G6M15_02655) 537298..537813 - 516 WP_174007784.1 MarR family transcriptional regulator -
G6M15_RS02660 (G6M15_02660) 537955..539484 + 1530 WP_174007788.1 MDR family MFS transporter -
G6M15_RS02665 (G6M15_02665) 539521..539820 - 300 WP_174007791.1 putative addiction module antidote protein Antitoxin
G6M15_RS02670 (G6M15_02670) 539801..540067 - 267 WP_211398631.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G6M15_RS02675 (G6M15_02675) 540354..541370 + 1017 WP_174007794.1 ligase-associated DNA damage response exonuclease -
G6M15_RS02680 (G6M15_02680) 541372..542997 + 1626 WP_174007797.1 cisplatin damage response ATP-dependent DNA ligase -
G6M15_RS02685 (G6M15_02685) 543152..544117 + 966 WP_174007799.1 prolyl oligopeptidase family serine peptidase -
G6M15_RS02690 (G6M15_02690) 544156..544590 - 435 WP_272447936.1 glycosyltransferase -
G6M15_RS02695 (G6M15_02695) 544615..544938 - 324 WP_236776969.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-80)

Antitoxin

Uncharacterized protein HI1420

(6-92)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 9800.24 Da        Isoelectric Point: 10.4496

>T269130 WP_211398631.1 NZ_CP116692:c540067-539801 [Agrobacterium tumefaciens]
MKDRTGKVRILHRLTAAEHGNFGDCEPVGGGVSEMRIHHGPGYRVYFTRIGKTIYFLLVGGDKSSQKRDIKRAIEMAQTI
GRDGRDGI

Download         Length: 267 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10844.35 Da        Isoelectric Point: 4.6286

>AT269130 WP_174007791.1 NZ_CP116692:c539820-539521 [Agrobacterium tumefaciens]
MAVTEFSKFDVSDYLDSDETMIEYLAVAMEDENPDVFIAALGAVARARGMSHVADVSGLGRESLYKALRPGSKLRYETVQ
RVLQALGFRLAVEKSLNAA

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References