Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2197244..2197788 | Replicon | chromosome |
| Accession | NC_017524 | ||
| Organism | Mycobacterium tuberculosis CTRI-2 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | MTCTRI2_RS10245 | Protein ID | WP_003409896.1 |
| Coordinates | 2197244..2197540 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | MTCTRI2_RS10250 | Protein ID | WP_003409899.1 |
| Coordinates | 2197537..2197788 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MTCTRI2_RS10190 | 2192277..2192627 | - | 351 | WP_003899096.1 | hypothetical protein | - |
| MTCTRI2_RS10195 | 2192638..2193540 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| MTCTRI2_RS10200 | 2193561..2193752 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| MTCTRI2_RS10205 | 2193753..2194049 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| MTCTRI2_RS10210 | 2194289..2194504 | + | 216 | WP_003409878.1 | antitoxin | - |
| MTCTRI2_RS10215 | 2194501..2194812 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| MTCTRI2_RS22475 | 2194786..2195307 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| MTCTRI2_RS10225 | 2195282..2195659 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| MTCTRI2_RS10230 | 2195701..2196150 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| MTCTRI2_RS10235 | 2196147..2196692 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| MTCTRI2_RS10240 | 2196581..2197195 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| MTCTRI2_RS10245 | 2197244..2197540 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| MTCTRI2_RS10250 | 2197537..2197788 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| MTCTRI2_RS10255 | 2197775..2198269 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| MTCTRI2_RS10260 | 2198429..2198836 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| MTCTRI2_RS10265 | 2198840..2199112 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| MTCTRI2_RS10270 | 2199145..2200365 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| MTCTRI2_RS10280 | 2201264..2202061 | + | 798 | WP_003899101.1 | ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T26913 WP_003409896.1 NC_017524:c2197540-2197244 [Mycobacterium tuberculosis CTRI-2]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T26913 NC_017524:c2197540-2197244 [Mycobacterium tuberculosis CTRI-2]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT26913 WP_003409899.1 NC_017524:c2197788-2197537 [Mycobacterium tuberculosis CTRI-2]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT26913 NC_017524:c2197788-2197537 [Mycobacterium tuberculosis CTRI-2]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |