Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 93526..94147 Replicon chromosome
Accession NZ_CP116688
Organism Agrobacterium tumefaciens strain LMG 292

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag G6L31_RS00450 Protein ID WP_173986218.1
Coordinates 93959..94147 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag G6L31_RS00445 Protein ID WP_080826623.1
Coordinates 93526..93954 (-) Length 143 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6L31_RS00420 (G6L31_000420) 88952..91123 + 2172 WP_236772994.1 TonB-dependent siderophore receptor -
G6L31_RS00425 (G6L31_000425) 91233..92114 + 882 WP_173986186.1 AraC family transcriptional regulator -
G6L31_RS00430 (G6L31_000430) 92244..92636 + 393 WP_035214685.1 PRC-barrel domain-containing protein -
G6L31_RS00435 (G6L31_000435) 92730..92972 - 243 WP_080826626.1 DUF982 domain-containing protein -
G6L31_RS00440 (G6L31_000440) 93290..93448 - 159 WP_020811433.1 YqaE/Pmp3 family membrane protein -
G6L31_RS00445 (G6L31_000445) 93526..93954 - 429 WP_080826623.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
G6L31_RS00450 (G6L31_000450) 93959..94147 - 189 WP_173986218.1 type II toxin-antitoxin system HicA family toxin Toxin
G6L31_RS00460 (G6L31_000460) 94532..95494 - 963 WP_173986187.1 nitronate monooxygenase family protein -
G6L31_RS00465 (G6L31_000465) 95749..96897 + 1149 WP_173986188.1 hypothetical protein -
G6L31_RS00470 (G6L31_000470) 96946..97827 - 882 WP_173986189.1 polyphosphate kinase 2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 6908.01 Da        Isoelectric Point: 11.1572

>T269123 WP_173986218.1 NZ_CP116688:c94147-93959 [Agrobacterium tumefaciens]
MKSGDIISALKADGWYEVGTRGSHVQFKHPTKQGRVTVPHPRRDLPIGTLKSIEKQSGLKLR

Download         Length: 189 bp

Antitoxin


Download         Length: 143 a.a.        Molecular weight: 15421.23 Da        Isoelectric Point: 4.2241

>AT269123 WP_080826623.1 NZ_CP116688:c93954-93526 [Agrobacterium tumefaciens]
MRNYIGLIHKDADSDYGVSFPDFPGVITAGTDLDDARHMAEEALALHVEGMIEDGEAIPEPSSLETVMADAENKDGVAIL
VTLKTESKKSVRINITLPEDVLKAIDAFAEARGLTRSGFLARAAKHEMSSVSEDDDWREFAA

Download         Length: 429 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References