Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 4814566..4815152 Replicon chromosome
Accession NZ_CP116682
Organism Pseudomonas aeruginosa strain HS337

Toxin (Protein)


Gene name PumA Uniprot ID G8CP73
Locus tag OK431_RS22830 Protein ID WP_003120987.1
Coordinates 4814853..4815152 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag OK431_RS22825 Protein ID WP_003448662.1
Coordinates 4814566..4814856 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OK431_RS22805 (OK431_22790) 4810142..4812037 + 1896 WP_234493604.1 hypothetical protein -
OK431_RS22810 (OK431_22795) 4812034..4814010 + 1977 WP_042931628.1 DEAD/DEAH box helicase -
OK431_RS22815 (OK431_22800) 4814020..4814154 + 135 WP_033179080.1 hypothetical protein -
OK431_RS22820 (OK431_22805) 4814151..4814495 + 345 WP_003448665.1 hypothetical protein -
OK431_RS22825 (OK431_22810) 4814566..4814856 - 291 WP_003448662.1 putative addiction module antidote protein Antitoxin
OK431_RS22830 (OK431_22815) 4814853..4815152 - 300 WP_003120987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OK431_RS22835 (OK431_22820) 4815354..4816475 + 1122 WP_003448658.1 TcpQ domain-containing protein -
OK431_RS22840 (OK431_22825) 4816475..4818184 + 1710 WP_010792227.1 PilN family type IVB pilus formation outer membrane protein -
OK431_RS22845 (OK431_22830) 4818188..4819513 + 1326 WP_003099758.1 type 4b pilus protein PilO2 -
OK431_RS22850 (OK431_22835) 4819503..4820036 + 534 WP_003099760.1 type IV pilus biogenesis protein PilP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4783323..4870689 87366


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11133.88 Da        Isoelectric Point: 10.4495

>T269117 WP_003120987.1 NZ_CP116682:c4815152-4814853 [Pseudomonas aeruginosa]
MVEVKQTATFMAWESKLKDRRAKAVIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQARDIEMAKRLANEWRPQ

Download         Length: 300 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.91 Da        Isoelectric Point: 4.7527

>AT269117 WP_003448662.1 NZ_CP116682:c4814856-4814566 [Pseudomonas aeruginosa]
MTEQIYDYDPAQALDSPEAMALFIADALDTGDTAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLA
VMRALGVDLTARPHAQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8CP73

Antitoxin

Source ID Structure

References