269116

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4677081..4678339 Replicon chromosome
Accession NZ_CP116682
Organism Pseudomonas aeruginosa strain HS337

Toxin (Protein)


Gene name - Uniprot ID Q9I4U4
Locus tag OK431_RS22040 Protein ID WP_003112528.1
Coordinates 4677081..4677836 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag OK431_RS22045 Protein ID WP_003086329.1
Coordinates 4677971..4678339 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OK431_RS22030 (OK431_22015) 4672254..4674797 + 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -
OK431_RS22035 (OK431_22020) 4674952..4676313 - 1362 WP_010895536.1 DNA recombination protein RmuC -
OK431_RS22040 (OK431_22025) 4677081..4677836 - 756 WP_003112528.1 RES family NAD+ phosphorylase Toxin
OK431_RS22045 (OK431_22030) 4677971..4678339 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
OK431_RS22050 (OK431_22035) 4678412..4679698 - 1287 WP_003112529.1 FAD-binding oxidoreductase -
OK431_RS22055 (OK431_22040) 4679754..4681247 - 1494 WP_003086325.1 aldehyde dehydrogenase family protein -
OK431_RS22060 (OK431_22045) 4681422..4681898 + 477 WP_003112531.1 hypothetical protein -
OK431_RS22065 (OK431_22050) 4681901..4682176 - 276 WP_010793902.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28278.42 Da        Isoelectric Point: 7.7294

>T269116 WP_003112528.1 NZ_CP116682:c4677836-4677081 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT269116 WP_003086329.1 NZ_CP116682:c4678339-4677971 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I4U4

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References