269115

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3696437..3697658 Replicon chromosome
Accession NZ_CP116682
Organism Pseudomonas aeruginosa strain HS337

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag OK431_RS17280 Protein ID WP_003102740.1
Coordinates 3697080..3697658 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag OK431_RS17275 Protein ID WP_003088112.1
Coordinates 3696437..3696991 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OK431_RS17250 (OK431_17235) 3692005..3692556 + 552 WP_004343115.1 XRE family transcriptional regulator -
OK431_RS17255 (OK431_17240) 3692553..3692951 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
OK431_RS17260 (OK431_17245) 3692964..3693287 - 324 WP_003102734.1 multidrug efflux SMR transporter -
OK431_RS17265 (OK431_17250) 3693618..3694079 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
OK431_RS17270 (OK431_17255) 3694084..3696279 + 2196 WP_010794059.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
OK431_RS17275 (OK431_17260) 3696437..3696991 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
OK431_RS17280 (OK431_17265) 3697080..3697658 + 579 WP_003102740.1 HD domain-containing protein Toxin
OK431_RS17285 (OK431_17270) 3697767..3698954 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
OK431_RS17290 (OK431_17275) 3698944..3701115 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
OK431_RS17295 (OK431_17280) 3701105..3702382 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T269115 WP_003102740.1 NZ_CP116682:3697080-3697658 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT269115 WP_003088112.1 NZ_CP116682:3696437-3696991 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References