Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2539570..2540086 Replicon chromosome
Accession NZ_CP116682
Organism Pseudomonas aeruginosa strain HS337

Toxin (Protein)


Gene name relE Uniprot ID A0A3R8UIH5
Locus tag OK431_RS12330 Protein ID WP_025297453.1
Coordinates 2539805..2540086 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3R8UIM7
Locus tag OK431_RS12325 Protein ID WP_025297454.1
Coordinates 2539570..2539815 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OK431_RS12310 (OK431_12305) 2535348..2537549 - 2202 WP_033976850.1 hypothetical protein -
OK431_RS12315 (OK431_12310) 2537647..2538723 - 1077 WP_052156709.1 WYL domain-containing protein -
OK431_RS12320 (OK431_12315) 2538881..2539135 - 255 WP_153574174.1 hypothetical protein -
OK431_RS12325 (OK431_12320) 2539570..2539815 + 246 WP_025297454.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
OK431_RS12330 (OK431_12325) 2539805..2540086 + 282 WP_025297453.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OK431_RS12335 (OK431_12330) 2540492..2541073 - 582 WP_033976848.1 plasmid pRiA4b ORF-3 family protein -
OK431_RS12340 (OK431_12335) 2541087..2541962 - 876 WP_033976847.1 WYL domain-containing protein -
OK431_RS12345 (OK431_12340) 2542092..2543672 + 1581 WP_070147860.1 DNA recombination protein RmuC -
OK431_RS12350 (OK431_12345) 2543696..2544343 + 648 WP_033976844.1 peptidase M15 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2528010..2571255 43245


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-71)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10824.61 Da        Isoelectric Point: 10.6249

>T269114 WP_025297453.1 NZ_CP116682:2539805-2540086 [Pseudomonas aeruginosa]
MTYELEFLPSALKEWQKLGHTVREQIKKKLRERLDNPKVQADALRDMPGHYKIKLRASGYRLVYRVEDERVVVVVVAVGK
RERGAAYQSAKGR

Download         Length: 282 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8797.21 Da        Isoelectric Point: 4.2550

>AT269114 WP_025297454.1 NZ_CP116682:2539570-2539815 [Pseudomonas aeruginosa]
MQSILADVAVSVSELKKNPSGILAGAGGMPVAVLNHNRVMGYMVPAELYEQMMERLDDLELVEIVKARSGEESVPVRLDD
L

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R8UIH5

Antitoxin

Source ID Structure
AlphaFold DB A0A3R8UIM7

References