269113

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1954737..1956245 Replicon chromosome
Accession NZ_CP116682
Organism Pseudomonas aeruginosa strain HS337

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag OK431_RS09335 Protein ID WP_003119682.1
Coordinates 1954737..1955324 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1C7C4U7
Locus tag OK431_RS09340 Protein ID WP_003091607.1
Coordinates 1955391..1956245 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OK431_RS09330 (OK431_09325) 1950992..1954471 - 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
OK431_RS09335 (OK431_09330) 1954737..1955324 + 588 WP_003119682.1 GNAT family protein Toxin
OK431_RS09340 (OK431_09335) 1955391..1956245 + 855 WP_003091607.1 AraC family transcriptional regulator Antitoxin
OK431_RS09345 (OK431_09340) 1956342..1958507 + 2166 WP_010793245.1 TonB-dependent receptor family protein -
OK431_RS09350 (OK431_09345) 1958682..1960556 + 1875 WP_010793244.1 MFS transporter -
OK431_RS09355 (OK431_09350) 1960617..1960826 - 210 WP_003091604.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T269113 WP_003119682.1 NZ_CP116682:1954737-1955324 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31895.20 Da        Isoelectric Point: 7.5295

>AT269113 WP_003091607.1 NZ_CP116682:1955391-1956245 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C4U7

References