Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 160105..160610 Replicon chromosome
Accession NZ_CP116682
Organism Pseudomonas aeruginosa strain HS337

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag OK431_RS00740 Protein ID WP_003083773.1
Coordinates 160105..160386 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag OK431_RS00745 Protein ID WP_003083775.1
Coordinates 160383..160610 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OK431_RS00715 (OK431_00715) 155356..156705 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
OK431_RS00720 (OK431_00720) 156754..157440 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
OK431_RS00725 (OK431_00725) 157541..158275 + 735 WP_003117208.1 GntR family transcriptional regulator -
OK431_RS00730 (OK431_00730) 158455..158865 + 411 WP_003101225.1 aegerolysin family protein -
OK431_RS00735 (OK431_00735) 158897..159805 - 909 WP_010793581.1 LysR family transcriptional regulator -
OK431_RS00740 (OK431_00740) 160105..160386 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
OK431_RS00745 (OK431_00745) 160383..160610 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
OK431_RS00750 (OK431_00750) 160786..161406 - 621 WP_003101226.1 hypothetical protein -
OK431_RS00755 (OK431_00755) 161507..162007 + 501 WP_003101228.1 LEA type 2 family protein -
OK431_RS00760 (OK431_00760) 162080..162421 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
OK431_RS00765 (OK431_00765) 162503..163930 - 1428 WP_003083784.1 GABA permease -
OK431_RS00770 (OK431_00770) 164099..165592 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T269111 WP_003083773.1 NZ_CP116682:c160386-160105 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT269111 WP_003083775.1 NZ_CP116682:c160610-160383 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References