Detailed information of TA system TA026911

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2188207..2188910
• Replicon: chromosome
• Accession: NC_017524
• Organism: Mycobacterium tuberculosis CTRI-2

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: G0TLK7
• Locus tag: MTCTRI2_RS10155
• Protein ID: WP_003409778.1
• Coordinates: 2188207..2188536 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: G0TLK8
• Locus tag: MTCTRI2_RS21285
• Protein ID: WP_003409780.1
• Coordinates: 2188533..2188910 (-)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTCTRI2_RS10135	2184590..2185660	+	1071	WP_003899091.1	epoxide hydrolase EphB	-
MTCTRI2_RS10140	2185657..2186172	+	516	WP_003409718.1	flavin reductase family protein	-
MTCTRI2_RS10145	2186169..2187230	+	1062	WP_003899092.1	3,4-dihydroxy-2-butanone-4-phosphate synthase	-
MTCTRI2_RS10150	2187227..2187997	+	771	WP_003409775.1	SDR family oxidoreductase	-
MTCTRI2_RS10155	2188207..2188536	-	330	WP_003409778.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
MTCTRI2_RS21285	2188533..2188910	-	378	WP_003409780.1	type II toxin-antitoxin system antitoxin MazE5	Antitoxin
MTCTRI2_RS10165	2188907..2189497	-	591	WP_003409784.1	SEC-C domain-containing protein	-
MTCTRI2_RS10170	2189552..2190916	+	1365	WP_014585532.1	HNH endonuclease	-
MTCTRI2_RS10175	2191071..2191523	-	453	WP_003899095.1	lipoprotein	-
MTCTRI2_RS10180	2191587..2191988	+	402	WP_003409869.1	hypothetical protein	-
MTCTRI2_RS10185	2191981..2192163	-	183	WP_003409870.1	hypothetical protein	-
MTCTRI2_RS10190	2192277..2192627	-	351	WP_003899096.1	hypothetical protein	-
MTCTRI2_RS10195	2192638..2193540	-	903	WP_003899097.1	hypothetical protein	-
MTCTRI2_RS10200	2193561..2193752	-	192	WP_003409876.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (7-103)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 11787.82 Da
• Isoelectric Point: 8.5361

>T26911 WP_003409778.1 NC_017524:c2188536-2188207 [Mycobacterium tuberculosis CTRI-2]
VTALPARGEVWWCEMAEIGRRPVVVLSRDAAIPRLRRALVAPCTTTIRGLASEVVLEPGSDPIPRRSAVNLDSVESVSVA
VLVNRLGRLADIRMRAICTALEVAVDCSR

Nucleotide

• Length: 330 bp

>T26911 NC_017524:c2188536-2188207 [Mycobacterium tuberculosis CTRI-2]
GTGACCGCACTTCCGGCGCGCGGAGAGGTGTGGTGGTGTGAGATGGCTGAGATCGGTCGGCGACCAGTCGTCGTGCTGTC
GCGCGATGCCGCGATCCCTCGGCTGCGACGCGCACTTGTCGCGCCCTGCACCACGACCATCCGAGGGCTAGCCAGTGAGG
TTGTTCTTGAACCCGGTTCCGACCCGATCCCGCGCCGTTCCGCGGTGAATTTGGACTCAGTCGAAAGTGTCTCGGTCGCG
GTATTGGTGAATCGGCTTGGCCGCCTCGCCGACATCCGGATGCGCGCCATCTGCACGGCCCTCGAGGTCGCCGTCGATTG
CTCTCGATGA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 13560.07 Da
• Isoelectric Point: 5.1519

>AT26911 WP_003409780.1 NC_017524:c2188910-2188533 [Mycobacterium tuberculosis CTRI-2]
VKTARLQVTLRCAVDLINSSSDQCFARIEHVASDQADPRPGVWHSSGMNRIRLSTTVDAALLTSARDMRAGITDAALIDE
ALAALLARHRSAEVDASYAAYDKHPVDEPDEWGDLASWRRAAGDS

Nucleotide

• Length: 378 bp

>AT26911 NC_017524:c2188910-2188533 [Mycobacterium tuberculosis CTRI-2]
GTGAAGACGGCCCGGTTGCAGGTGACGTTGCGCTGCGCGGTAGACCTCATCAATTCGTCCAGCGACCAATGTTTCGCCCG
TATCGAGCACGTTGCGTCCGATCAGGCGGATCCACGCCCCGGAGTGTGGCATAGTAGTGGCATGAATCGCATACGGCTGA
GCACTACTGTCGACGCCGCACTCTTGACAAGTGCGCGCGACATGCGGGCAGGAATCACTGACGCAGCCCTCATCGATGAG
GCCCTTGCGGCATTACTGGCTCGTCATCGATCGGCCGAGGTGGATGCCAGCTATGCGGCCTACGACAAGCACCCGGTCGA
TGAGCCCGACGAGTGGGGCGATCTAGCGTCGTGGCGGCGGGCGGCTGGAGACTCGTGA

Structures

Toxin

• AlphaFold DB: G0TLK7

Antitoxin

• AlphaFold DB: G0TLK8