Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 111390..111967 Replicon plasmid pEtSC002-3
Accession NZ_CP116678
Organism Edwardsiella tarda strain SC002

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag PHA77_RS18800 Protein ID WP_279509954.1
Coordinates 111635..111967 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag PHA77_RS18795 Protein ID WP_279509953.1
Coordinates 111390..111635 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PHA77_RS18770 (PHA77_18770) 106444..107403 - 960 WP_279509948.1 Rpn family recombination-promoting nuclease/putative transposase -
PHA77_RS18775 (PHA77_18775) 107711..109225 + 1515 Protein_107 IS21 family transposase -
PHA77_RS18780 (PHA77_18780) 109249..110004 + 756 WP_279509949.1 IS21-like element helper ATPase IstB -
PHA77_RS18785 (PHA77_18785) 110338..110607 + 270 WP_279509951.1 hypothetical protein -
PHA77_RS18790 (PHA77_18790) 110595..111224 + 630 WP_279509952.1 hypothetical protein -
PHA77_RS18795 (PHA77_18795) 111390..111635 + 246 WP_279509953.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
PHA77_RS18800 (PHA77_18800) 111635..111967 + 333 WP_279509954.1 endoribonuclease MazF Toxin
PHA77_RS18805 (PHA77_18805) 112091..112741 - 651 Protein_113 IS630 family transposase -
PHA77_RS18810 (PHA77_18810) 112844..113518 + 675 Protein_114 IS21 family transposase -
PHA77_RS18815 (PHA77_18815) 113743..114966 + 1224 WP_279509955.1 IS91 family transposase -
PHA77_RS18820 (PHA77_18820) 115518..116501 - 984 WP_068872129.1 ParB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..154848 154848
- inside IScluster/Tn - - 107929..113338 5409


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-109)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11957.89 Da        Isoelectric Point: 8.2674

>T269108 WP_279509954.1 NZ_CP116678:111635-111967 [Edwardsiella tarda]
MVSRFVPDSGDLIWIDFDPVAGHEQGGKRPAVVLSPFAYNNKVGLLLCVPCTTKVKNYPFEVELSGERDSVALADQITCV
DWRARKVTKKGAISAIELADIRAKAKALIG

Download         Length: 333 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8743.15 Da        Isoelectric Point: 4.5026

>AT269108 WP_279509953.1 NZ_CP116678:111390-111635 [Edwardsiella tarda]
MAQVVVKKWGNSPSVRLPVAIMQAASLNVDDTVDIAVEDGRIVIIPVKAKEYSLDALLAGITEDNIHERMGFGEPVGKEL
L

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References