Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2576382..2576974 Replicon chromosome
Accession NZ_CP116675
Organism Edwardsiella tarda strain SC002

Toxin (Protein)


Gene name Hha Uniprot ID D4F316
Locus tag PHA77_RS12035 Protein ID WP_005283517.1
Coordinates 2576771..2576974 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID D4F317
Locus tag PHA77_RS12030 Protein ID WP_005283520.1
Coordinates 2576382..2576750 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PHA77_RS12020 (PHA77_12020) 2571624..2572808 + 1185 WP_005296656.1 efflux RND transporter periplasmic adaptor subunit -
PHA77_RS12025 (PHA77_12025) 2572853..2576008 + 3156 WP_005283526.1 efflux RND transporter permease subunit -
PHA77_RS12030 (PHA77_12030) 2576382..2576750 + 369 WP_005283520.1 Hha toxicity modulator TomB Antitoxin
PHA77_RS12035 (PHA77_12035) 2576771..2576974 + 204 WP_005283517.1 HHA domain-containing protein Toxin
PHA77_RS12045 (PHA77_12045) 2577927..2578250 + 324 WP_068869962.1 MGMT family protein -
PHA77_RS12050 (PHA77_12050) 2578331..2579197 + 867 WP_068869964.1 acyl-CoA thioesterase II -
PHA77_RS12055 (PHA77_12055) 2579222..2580499 - 1278 WP_035594812.1 ammonium transporter AmtB -
PHA77_RS12060 (PHA77_12060) 2580526..2580864 - 339 WP_035594810.1 P-II family nitrogen regulator -
PHA77_RS12065 (PHA77_12065) 2581144..2581605 - 462 WP_005296844.1 Lrp/AsnC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8088.36 Da        Isoelectric Point: 5.8288

>T269104 WP_005283517.1 NZ_CP116675:2576771-2576974 [Edwardsiella tarda]
MTKIDYLMKLRKCTSLETLERVIEKNKYELSNDELEVFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14260.05 Da        Isoelectric Point: 6.0582

>AT269104 WP_005283520.1 NZ_CP116675:2576382-2576750 [Edwardsiella tarda]
MDEYTSYRHDIAELKYLCDSLYRQGMDVLEESHHGWVSDPTAMVNLQLNELIEHIANVALSFKIKYPQHSSLCEIVDDYL
DETYALFSAYSVSEQALRHWLRSKRRVAYSLAHEKRNAALHV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D4F316

Antitoxin

Source ID Structure
AlphaFold DB D4F317

References