Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 1947137..1947659 Replicon chromosome
Accession NZ_CP116675
Organism Edwardsiella tarda strain SC002

Toxin (Protein)


Gene name relE Uniprot ID D4F5Y1
Locus tag PHA77_RS09040 Protein ID WP_005286355.1
Coordinates 1947378..1947659 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D4F5Y0
Locus tag PHA77_RS09035 Protein ID WP_005286352.1
Coordinates 1947137..1947388 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PHA77_RS09005 (PHA77_09005) 1942405..1943067 - 663 WP_077999886.1 hypothetical protein -
PHA77_RS09010 (PHA77_09010) 1943067..1943648 - 582 WP_279508081.1 hypothetical protein -
PHA77_RS09015 (PHA77_09015) 1943635..1944099 - 465 WP_279508083.1 hypothetical protein -
PHA77_RS09020 (PHA77_09020) 1944141..1944542 - 402 WP_279508085.1 hypothetical protein -
PHA77_RS09025 (PHA77_09025) 1944604..1945842 - 1239 WP_279508087.1 N4-gp56 family major capsid protein -
PHA77_RS09030 (PHA77_09030) 1945860..1946858 - 999 WP_279508089.1 hypothetical protein -
PHA77_RS09035 (PHA77_09035) 1947137..1947388 + 252 WP_005286352.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PHA77_RS09040 (PHA77_09040) 1947378..1947659 + 282 WP_005286355.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PHA77_RS09045 (PHA77_09045) 1947731..1949845 - 2115 WP_279508093.1 portal protein -
PHA77_RS09050 (PHA77_09050) 1949842..1951503 - 1662 WP_181367145.1 terminase -
PHA77_RS09055 (PHA77_09055) 1951496..1951891 - 396 WP_279508096.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1921259..1990509 69250


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10852.69 Da        Isoelectric Point: 10.7535

>T269102 WP_005286355.1 NZ_CP116675:1947378-1947659 [Edwardsiella tarda]
MTYKLSFEKRALKEWKRLAPPIQSQLKKKLIERLENPHVPAARLSGRANRYKIKLRASGYRLVYEVNDNEIILLVIAIGK
RADNEVYQTADSR

Download         Length: 282 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9128.22 Da        Isoelectric Point: 3.7550

>AT269102 WP_005286352.1 NZ_CP116675:1947137-1947388 [Edwardsiella tarda]
MAYQILTTTAASITDLKRNPMGTIAEGDGNAVAILNRNEPAFYCVPPELYAYYLELAEDAALNRIADERLEDAEFVSVSI
DDL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D4F5Y1

Antitoxin

Source ID Structure
AlphaFold DB D4F5Y0

References