Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 563175..563844 Replicon chromosome
Accession NZ_CP116675
Organism Edwardsiella tarda strain SC002

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A7U6Y8
Locus tag PHA77_RS02590 Protein ID WP_005296363.1
Coordinates 563422..563844 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A2A7U0A3
Locus tag PHA77_RS02585 Protein ID WP_005296359.1
Coordinates 563175..563441 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PHA77_RS02565 (PHA77_02565) 558411..559061 - 651 WP_077999838.1 hemolysin III family protein -
PHA77_RS02570 (PHA77_02570) 559637..560521 + 885 WP_279509088.1 nucleoside-specific channel-forming protein Tsx -
PHA77_RS02575 (PHA77_02575) 560731..561555 + 825 WP_097364355.1 shikimate 5-dehydrogenase -
PHA77_RS02580 (PHA77_02580) 561608..562603 - 996 WP_279509090.1 tRNA-modifying protein YgfZ -
PHA77_RS02585 (PHA77_02585) 563175..563441 + 267 WP_005296359.1 FAD assembly factor SdhE Antitoxin
PHA77_RS02590 (PHA77_02590) 563422..563844 + 423 WP_005296363.1 protein YgfX Toxin
PHA77_RS02595 (PHA77_02595) 563928..564446 - 519 WP_005282086.1 flavodoxin FldB -
PHA77_RS02600 (PHA77_02600) 564584..565483 + 900 WP_005282082.1 site-specific tyrosine recombinase XerD -
PHA77_RS02605 (PHA77_02605) 565511..566227 + 717 WP_005282080.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PHA77_RS02610 (PHA77_02610) 566232..567965 + 1734 WP_005296366.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-134)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16231.84 Da        Isoelectric Point: 9.3042

>T269097 WP_005296363.1 NZ_CP116675:563422-563844 [Edwardsiella tarda]
VAPWCCNVHVSWRTQVIALLGYGALVLTILLAPWPESYGVSAFWLLLLVVVIFECIRSQRRIARNRGELQYSATGEWRWQ
QREWRLARRPWISDMGVLLLLQSSAGPARRRRLWLAADSMSQEEWSELRALLLNAPETND

Download         Length: 423 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10325.96 Da        Isoelectric Point: 5.6819

>AT269097 WP_005296359.1 NZ_CP116675:563175-563441 [Edwardsiella tarda]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDAMSDADKQTFVRLLNCDDPELFKWLMNQGVPEDADLARMITLIQTRN
KARGPMVL

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A7U6Y8

Antitoxin

Source ID Structure
AlphaFold DB A0A2A7U0A3

References