Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1460656..1461434 Replicon chromosome
Accession NZ_CP116672
Organism Xanthomonas hortorum pv. pelargonii strain 305

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag PML25_RS06065 Protein ID WP_168958945.1
Coordinates 1460656..1461147 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag PML25_RS06070 Protein ID WP_168958946.1
Coordinates 1461144..1461434 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PML25_RS06050 (PML25_06050) 1457239..1458159 + 921 WP_168958943.1 30S ribosomal protein S6--L-glutamate ligase -
PML25_RS06055 (PML25_06055) 1458503..1459180 + 678 WP_006448355.1 response regulator transcription factor -
PML25_RS06060 (PML25_06060) 1459173..1460507 + 1335 WP_168958944.1 HAMP domain-containing sensor histidine kinase -
PML25_RS06065 (PML25_06065) 1460656..1461147 - 492 WP_168958945.1 GNAT family N-acetyltransferase Toxin
PML25_RS06070 (PML25_06070) 1461144..1461434 - 291 WP_168958946.1 DUF1778 domain-containing protein Antitoxin
PML25_RS06075 (PML25_06075) 1461510..1461911 - 402 WP_168958947.1 SymE family type I addiction module toxin -
PML25_RS06080 (PML25_06080) 1462440..1463063 - 624 WP_168958948.1 dephospho-CoA kinase -
PML25_RS06085 (PML25_06085) 1463077..1463940 - 864 WP_016849610.1 A24 family peptidase -
PML25_RS06090 (PML25_06090) 1463947..1465206 - 1260 WP_168958949.1 type II secretion system F family protein -
PML25_RS06095 (PML25_06095) 1465558..1465983 + 426 WP_168958950.1 pilin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1416869..1493280 76411


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17592.27 Da        Isoelectric Point: 9.6230

>T269091 WP_168958945.1 NZ_CP116672:c1461147-1460656 [Xanthomonas hortorum pv. pelargonii]
MTVSAPEPLTAHHRVEPFASGVESLDHWLKRRALKNQATGASRTFVACADDRVVAYYALASSAVAVDATPGRFRRNMPDP
IPVVVLGRLAVDQSLHGRGFGRALVRDAGKRVLHAADTIGIRGLLVHALSTDAKAFYERIGFEPSPLDPMVLVVTLEDLK
ASL

Download         Length: 492 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10616.14 Da        Isoelectric Point: 10.5480

>AT269091 WP_168958946.1 NZ_CP116672:c1461434-1461144 [Xanthomonas hortorum pv. pelargonii]
MSTPNTTPGKRETLNLRIKPEERSLIDRAAKARGKNRTDFVLDAARSAAEEALLDQTLIAASPDAYAAFLARLDMPPQPN
ARLRKTMQTPAPWEKA

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References