Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3545668..3547415 Replicon chromosome
Accession NZ_CP116621
Organism Proteus terrae strain TP22

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag ONR67_RS16400 Protein ID WP_271976551.1
Coordinates 3545668..3547041 (+) Length 458 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag ONR67_RS16405 Protein ID WP_098941871.1
Coordinates 3547038..3547415 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ONR67_RS16385 (ONR67_16385) 3541340..3542323 - 984 WP_075673449.1 ABC transporter permease -
ONR67_RS16390 (ONR67_16390) 3542308..3543891 - 1584 WP_271976549.1 ABC transporter substrate-binding protein -
ONR67_RS16395 (ONR67_16395) 3544296..3545285 - 990 WP_191901568.1 glycosyltransferase -
ONR67_RS16400 (ONR67_16400) 3545668..3547041 + 1374 WP_271976551.1 HipA domain-containing protein Toxin
ONR67_RS16405 (ONR67_16405) 3547038..3547415 + 378 WP_098941871.1 helix-turn-helix transcriptional regulator Antitoxin
ONR67_RS16410 (ONR67_16410) 3547537..3548037 - 501 WP_075673444.1 hydrogenase maturation peptidase HycI -
ONR67_RS16415 (ONR67_16415) 3548034..3548444 - 411 WP_088494545.1 formate hydrogenlyase maturation HycH family protein -
ONR67_RS16420 (ONR67_16420) 3548437..3549219 - 783 WP_099659719.1 NADH-quinone oxidoreductase subunit B family protein -
ONR67_RS16425 (ONR67_16425) 3549216..3549770 - 555 WP_075673442.1 hydrogenase 4 subunit H -
ONR67_RS16430 (ONR67_16430) 3549782..3551515 - 1734 WP_075673441.1 hydrogenase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(174-418)

Antitoxin

Cro/C1-type helix-turn-helix domain

(48-103)


Sequences

Toxin        


Download         Length: 458 a.a.        Molecular weight: 52616.47 Da        Isoelectric Point: 4.6415

>T269087 WP_271976551.1 NZ_CP116621:3545668-3547041 [Proteus terrae]
MEKITLQAFLNQEWVDIAIINFPKYDRMLYANKYDITYPITELEYETSYSIEHLYQDDQHAVSINHPVELYFDDSGSPGW
LKFLDDIVPSGASRRYWLQYLDIAELSTEQQNYELLHHGTISPIGNLRVKESLPAPSPLNRNLFFTINDVKNRASDFLDY
AQRKGAAAGGATGAGGEAPKLLLRCNDNEEVWIDTYQDDISNLDKYYLVKFPRGSRSVVDCNILRTEYHFYHELTDMGFD
TIPIKDMRLEEGDNYPSLWLPRFDIKIENNKIIRLAMESVYSILNKAPGTTLYHETVIKELIDKINQSNMVTEFGFQFNT
ANFIIEWVRRDLLNIIFGNSDNHGRNTSLIRYNNAIYLAPIYDFAPMKADPEGIARTTKWGSHSEIGGEYNFINIADSLS
DLIAPEQLLNALQETAQQLLTLKERLEMRGVPTQILTMPSFGFDFIPNKLERWGLLP

Download         Length: 1374 bp

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14108.43 Da        Isoelectric Point: 10.5220

>AT269087 WP_098941871.1 NZ_CP116621:3547038-3547415 [Proteus terrae]
MNNVENKNHIDKFPTRASRKHQFVATTDRKQVISKIMAHLLFGEITQGEALKMLRIKVLGLNQDLYAKLINVSRKTLSEI
ENDRGNYSADIINKVFKPFGLKVGLVPSSPHILSSLLKESPPINE

Download         Length: 378 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References