Detailed information of TA system TA269086

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3434899..3436621
• Replicon: chromosome
• Accession: NZ_CP116621
• Organism: Proteus terrae strain TP22

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: ONR67_RS15960
• Protein ID: WP_170355928.1
• Coordinates: 3434899..3435837 (-)
• Length: 313 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: ONR67_RS15965
• Protein ID: WP_170355935.1
• Coordinates: 3435845..3436621 (-)
• Length: 259 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ONR67_RS15940 (ONR67_15940)	3430840..3431352	-	513	WP_170355924.1	S26 family signal peptidase	-
ONR67_RS15945 (ONR67_15945)	3431336..3431683	-	348	WP_156734078.1	plasmid-related protein	-
ONR67_RS15950 (ONR67_15950)	3431676..3434075	-	2400	WP_170355926.1	type IV secretion system protein TraC	-
ONR67_RS15955 (ONR67_15955)	3434075..3434767	-	693	WP_001228924.1	DsbC family protein	-
ONR67_RS15960 (ONR67_15960)	3434899..3435837	-	939	WP_170355928.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
ONR67_RS15965 (ONR67_15965)	3435845..3436621	-	777	WP_170355935.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
ONR67_RS15970 (ONR67_15970)	3436841..3437227	-	387	WP_000180225.1	TraA family conjugative transfer protein	-
ONR67_RS15975 (ONR67_15975)	3437224..3437796	-	573	WP_001944091.1	type IV conjugative transfer system lipoprotein TraV	-
ONR67_RS15980 (ONR67_15980)	3437871..3439160	-	1290	WP_170383165.1	TraB/VirB10 family protein	-
ONR67_RS15985 (ONR67_15985)	3439163..3440059	-	897	WP_170355937.1	type-F conjugative transfer system secretin TraK	-
ONR67_RS15990 (ONR67_15990)	3440043..3440669	-	627	WP_000667170.1	TraE/TraK family type IV conjugative transfer system protein	-
ONR67_RS15995 (ONR67_15995)	3440666..3440947	-	282	WP_000433891.1	type IV conjugative transfer system protein TraL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(H) / sul2 / aph(3'')-Ib / aph(6)-Id / aph(3')-VIa / tet(A) / floR	-	3325553..3505258	179705

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-97)

Sequences

Toxin

Protein

• Length: 313 a.a.
• Molecular weight: 35664.00 Da
• Isoelectric Point: 5.2653

>T269086 WP_170355928.1 NZ_CP116621:c3435837-3434899 [Proteus terrae]
MDKYSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMAVQESVEYEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGVSREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYRNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE

Nucleotide

• Length: 939 bp

Antitoxin

Protein

• Length: 259 a.a.
• Molecular weight: 29578.97 Da
• Isoelectric Point: 9.3775

>AT269086 WP_170355935.1 NZ_CP116621:c3436621-3435845 [Proteus terrae]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLCSGVYYRPDAQGDIKPTWVDAIQALDVQLGVSVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKRG

Nucleotide

• Length: 777 bp