Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3473915..3475656 Replicon chromosome
Accession NZ_CP116620
Organism Proteus terrae strain CZP50

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag ONR71_RS16060 Protein ID WP_098941872.1
Coordinates 3473915..3475288 (+) Length 458 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag ONR71_RS16065 Protein ID WP_159241810.1
Coordinates 3475285..3475656 (+) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ONR71_RS16045 (ONR71_16045) 3469587..3470570 - 984 WP_075673449.1 ABC transporter permease -
ONR71_RS16050 (ONR71_16050) 3470555..3472138 - 1584 WP_099659717.1 ABC transporter substrate-binding protein -
ONR71_RS16055 (ONR71_16055) 3472544..3473533 - 990 WP_159241809.1 glycosyltransferase -
ONR71_RS16060 (ONR71_16060) 3473915..3475288 + 1374 WP_098941872.1 HipA domain-containing protein Toxin
ONR71_RS16065 (ONR71_16065) 3475285..3475656 + 372 WP_159241810.1 helix-turn-helix domain-containing protein Antitoxin
ONR71_RS16070 (ONR71_16070) 3475785..3476285 - 501 WP_075673444.1 hydrogenase maturation peptidase HycI -
ONR71_RS16075 (ONR71_16075) 3476282..3476692 - 411 WP_088494545.1 formate hydrogenlyase maturation HycH family protein -
ONR71_RS16080 (ONR71_16080) 3476685..3477467 - 783 WP_072069032.1 NADH-quinone oxidoreductase subunit B family protein -
ONR71_RS16085 (ONR71_16085) 3477464..3478018 - 555 WP_075673442.1 hydrogenase 4 subunit H -
ONR71_RS16090 (ONR71_16090) 3478030..3479763 - 1734 WP_075673441.1 hydrogenase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(174-418)

Antitoxin

Cro/C1-type helix-turn-helix domain

(48-103)


Sequences

Toxin        


Download         Length: 458 a.a.        Molecular weight: 52589.44 Da        Isoelectric Point: 4.6415

>T269081 WP_098941872.1 NZ_CP116620:3473915-3475288 [Proteus terrae]
MEKITLQAFLNQEWVDIAIINFPKYDRMLYASKYDITYPITELEYETSYSIEHLYQDDQHAVSINHPVELYFDDSGSPGW
LKFLDDIVPSGASRRYWLQYLDIAELSTEQQNYELLHHGTISPIGNLRVKESLPAPSPLNRNLFFTINDVKNRASDFLDY
AQRKGAAAGGATGAGGEAPKLLLRCNDNEEVWIDTYQDDISNLDKYYLVKFPRGSRSVVDCNILRTEYHFYHELTDMGFD
TIPIKDMRLEEGDNYPSLWLPRFDIKIENNKIIRLAMESVYSILNKAPGTTLYHETVIKELIDKINQSNMVTEFGFQFNT
ANFIIEWVRRDLLNIIFGNSDNHGRNTSLIRYNNAIYLAPIYDFAPMKADPEGIARTTKWGSHSEIGGEYNFINIADSLS
DLIAPEQLLNALQETAQQLLTLKERLEMRGVPTQILTMPSFGFDFIPNKLERWGLLP

Download         Length: 1374 bp

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13856.12 Da        Isoelectric Point: 10.6462

>AT269081 WP_159241810.1 NZ_CP116620:3475285-3475656 [Proteus terrae]
MNNVENKNHIDKFPTRASRKHQFVATTDRKQVISKIMAHLLFGEITQGEALKMLRIKVLGLNQDLYAKLINVSRKTLSEI
ENDRGNYSADIINKVFKPFGLKVGLVPSSPHILSSLLKESPSN

Download         Length: 372 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References