Detailed information of TA system TA269080

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3397043..3398765
• Replicon: chromosome
• Accession: NZ_CP116620
• Organism: Proteus terrae strain CZP50

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A0U2S2I2
• Locus tag: ONR71_RS15730
• Protein ID: WP_064497040.1
• Coordinates: 3397043..3397981 (-)
• Length: 313 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A0A934MVJ4
• Locus tag: ONR71_RS15735
• Protein ID: WP_000095577.1
• Coordinates: 3397974..3398765 (-)
• Length: 264 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ONR71_RS15710 (ONR71_15710)	3392984..3393496	-	513	WP_175215521.1	S26 family signal peptidase	-
ONR71_RS15715 (ONR71_15715)	3393480..3393827	-	348	WP_064497038.1	hypothetical protein	-
ONR71_RS15720 (ONR71_15720)	3393820..3396219	-	2400	WP_064497039.1	type IV secretion system protein TraC	-
ONR71_RS15725 (ONR71_15725)	3396219..3396911	-	693	WP_001228924.1	DsbC family protein	-
ONR71_RS15730 (ONR71_15730)	3397043..3397981	-	939	WP_064497040.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
ONR71_RS15735 (ONR71_15735)	3397974..3398765	-	792	WP_000095577.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
ONR71_RS15740 (ONR71_15740)	3398986..3399372	-	387	WP_032469918.1	TraA family conjugative transfer protein	-
ONR71_RS15745 (ONR71_15745)	3399369..3399941	-	573	WP_024008834.1	type IV conjugative transfer system lipoprotein TraV	-
ONR71_RS15750 (ONR71_15750)	3400016..3401305	-	1290	WP_064497041.1	TraB/VirB10 family protein	-
ONR71_RS15755 (ONR71_15755)	3401308..3402204	-	897	WP_064497055.1	type-F conjugative transfer system secretin TraK	-
ONR71_RS15760 (ONR71_15760)	3402188..3402814	-	627	WP_064497042.1	TraE/TraK family type IV conjugative transfer system protein	-
ONR71_RS15765 (ONR71_15765)	3402811..3403092	-	282	WP_000433891.1	type IV conjugative transfer system protein TraL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(H) / aadA2 / ere(A) / dfrA32 / cfr / sul1 / qacE / ARR-3 / catB3 / blaOXA-1 / aac(6')-Ib-cr / aph(3')-Ia / tet(C)	-	3266757..3413925	147168

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-272)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (99-250)

Sequences

Toxin

Protein

• Length: 313 a.a.
• Molecular weight: 35542.81 Da
• Isoelectric Point: 4.9912

>T269080 WP_064497040.1 NZ_CP116620:c3397981-3397043 [Proteus terrae]
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIIVSSPVATIKIEVSPVARGTLHSAEIMAVQESVEYEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGVSREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLTSLQK
HFTERDYAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE

Nucleotide

• Length: 939 bp

>T269080 NZ_CP116620:c3397981-3397043 [Proteus terrae]
ATGGATAAAGATAGCCCATATTACAAACAGGTTTCTTTGCTCATAAGAATGCTGCCTGTGGTAGCAACAGAGACGGTTTT
TGCACTTAAAGGTGGCACCGCCATTAATTTATTTGTGAGAGATTTTCCTCGGTTATCTGTAGATATTGATCTTGCTTATC
TTCCACTTGAACCAAGAGATGAGGCTTTGATTAATGTCAGGGCTGCATTGCAGCGCATTACAGACAGAATCAATACTCAA
CCAGATATCAGAGCGGCATTTCAGGATAATAAAGCTGATGAACTGAGAATAATTGTATCAAGTCCGGTTGCGACGATCAA
AATTGAAGTGTCGCCCGTCGCCAGAGGTACATTGCATAGTGCAGAAATAATGGCAGTTCAAGAGTCTGTTGAATACGAGT
TTGGTTATGCTGAGATTCAGGTAGTCAGTCTTCCCGATCTGTATGGTGGGAAATTGTGTGCTGCAATGGATCGCCAACAT
CCTCGCGACTTATTTGATGTGCGTATGTTACTTGGCAGTGAAGGGGTTTCGAGAGAGATTTTAGTGGGTTTTTTAACCTA
TACATTAAGTCATCCTCGGCCTATTAATGAAGTCATGTCGCCAAACTGGCAGCCGCTGAATGAGAAATTTCAGGCAGAAT
TTGATGGAATGACTTTTGAAAAAGTTGAATGCGAAGACTTAGCTTCTGTTAGGCCTATGATGTTAACTTCGCTGCAAAAA
CATTTCACAGAAAGGGATTATGCTTTCCTTATGTCATTCAAAAGAGGGCAACCTGACTGGGCATTGTTTGACTATCCTAA
TGCAGCAGACTTGCCAGCGATTCGTTGGAAGTTGCAGAACATAAACAAATTGGCAAAGAATCAAGCAAAACATCAAGAGC
AATTAGATAAATTGAAGCAAGTGCTTGATGATTGGCTTGTTAACGCAAACGCCGAGTAA

Antitoxin

Protein

• Length: 264 a.a.
• Molecular weight: 30109.49 Da
• Isoelectric Point: 9.5097

>AT269080 WP_000095577.1 NZ_CP116620:c3398765-3397974 [Proteus terrae]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVPVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG

Nucleotide

• Length: 792 bp

>AT269080 NZ_CP116620:c3398765-3397974 [Proteus terrae]
ATGTCATCTAAAATAAACTGGCTTGTTGCTCATACTTCTCCTGGTGCGCTAGTACTTCAGCAATGGCTGACTGAAAACGG
CGTGAGCTACTCGTTGGCTCAAAAGTACGCGCAGAACGGTTGGCTGAAGAAGCTTAGTTCTGGTGTGTACTATCGTCCAA
ATGCGCAGGGCGATATAAAGCCAACTTGGGTTGATGCCATTCAAGCATTGGATGTGCAATTGGGCGTTCCAGTTCATTTG
GCTGGATTGAGCAGCTTAACTCACCAAGGACTGAGTCACTATTTGCAGCTGAACAAAGAGCAAGTTTGGATTTGCGTTAA
AAACAAGTCGTCCTTACCGAAATGGTTTCGTGAATTCCCTTATCAGAATTGGTTTTACTGCGGAAACCATAAGCTTGAAG
TGAATCCCGAGAAAGATTTGAAAAGGATCACGGTTAAAGAGAAAGAGCTCACTGTCAGCTGTGCAGAACTTGCTGCCTAT
GAAGTGGTAGATGCGATTGGAAAGCTGATTTCATTTGAGCATGTCGCAGAATTATTTCAGGGTTTAGTCAATCTTAGCCC
TAGAAAAGTACAAGATATTCTTGAACGAAGCAGCTCTGTTCAGGCAAACCGAATATTTCTATTTCTGGGTCGATACTACG
ATCACCAGTGGGTCAATCGCATAGATGAAACAAGAATTAAATTGGGGGCAGGAAAGCGGCAGGTTGTCGAAAAAGGACGT
TTTGATGAGCGATATCAAATCACAGTGCCAGAGATATTAAGCGTCAAAAAAGGTGAACAACATAATGGATAA

Structures

Toxin

• AlphaFold DB: A0A0U2S2I2