Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 2194492..2194975 Replicon chromosome
Accession NZ_CP116604
Organism Streptococcus sp. HN38

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag PHA78_RS10675 Protein ID WP_024378848.1
Coordinates 2194492..2194752 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag PHA78_RS10680 Protein ID WP_024378847.1
Coordinates 2194754..2194975 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PHA78_RS10655 2190510..2190881 - 372 WP_024378851.1 hypothetical protein -
PHA78_RS10660 2190891..2192945 - 2055 WP_024378850.1 ATP-binding cassette domain-containing protein -
PHA78_RS10665 2193083..2193208 - 126 WP_257212219.1 hypothetical protein -
PHA78_RS10670 2193404..2194294 + 891 WP_024378849.1 helix-turn-helix transcriptional regulator -
PHA78_RS10675 2194492..2194752 - 261 WP_024378848.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PHA78_RS10680 2194754..2194975 - 222 WP_024378847.1 DUF6290 family protein Antitoxin
PHA78_RS10685 2195088..2195534 - 447 WP_272158567.1 transposase -
PHA78_RS10690 2195607..2195933 - 327 WP_272158155.1 IS630 transposase-related protein -
PHA78_RS10695 2195979..2196764 - 786 WP_024378844.1 Sua5/YciO/YrdC/YwlC family protein -
PHA78_RS10700 2197104..2197697 - 594 WP_172145390.1 3-isopropylmalate dehydratase small subunit -
PHA78_RS10705 2197697..2199088 - 1392 WP_272158157.1 3-isopropylmalate dehydratase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10347.93 Da        Isoelectric Point: 9.8449

>T269072 WP_024378848.1 NZ_CP116604:c2194752-2194492 [Streptococcus sp. HN38]
MFHVEYSKKAQRQIRKLDKPIQRLLFAWVDKHLDGTVNPRLHGKGLTGDHANEWRYRIGDYRLICDIQDDRMVILALEFG
HRRDIY

Download         Length: 261 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8623.60 Da        Isoelectric Point: 4.4915

>AT269072 WP_024378847.1 NZ_CP116604:c2194975-2194754 [Streptococcus sp. HN38]
MSTVTIRLNKEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLNIYHQAYEEYQKDPETISHADFKKELGL

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References