Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1682078..1682682 Replicon chromosome
Accession NZ_CP116604
Organism Streptococcus sp. HN38

Toxin (Protein)


Gene name hicA Uniprot ID A0A0M9FK57
Locus tag PHA78_RS08105 Protein ID WP_024375895.1
Coordinates 1682078..1682269 (+) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0M9FJP6
Locus tag PHA78_RS08110 Protein ID WP_024375896.1
Coordinates 1682305..1682682 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PHA78_RS08090 1680464..1680610 + 147 Protein_1553 AraC family transcriptional regulator -
PHA78_RS08095 1680998..1681633 - 636 Protein_1554 site-specific integrase -
PHA78_RS08100 1681721..1681909 + 189 WP_238595224.1 hypothetical protein -
PHA78_RS08105 1682078..1682269 + 192 WP_024375895.1 type II toxin-antitoxin system HicA family toxin Toxin
PHA78_RS08110 1682305..1682682 + 378 WP_024375896.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PHA78_RS08115 1683004..1685271 - 2268 WP_272157956.1 glycogen/starch/alpha-glucan phosphorylase -
PHA78_RS08120 1685409..1686122 - 714 WP_104930709.1 purine-nucleoside phosphorylase -
PHA78_RS08125 1686155..1686964 - 810 WP_014638303.1 purine-nucleoside phosphorylase -
PHA78_RS08130 1686976..1687332 - 357 WP_104930708.1 ArsC/Spx/MgsR family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-62)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-106)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 7017.28 Da        Isoelectric Point: 10.6194

>T269071 WP_024375895.1 NZ_CP116604:1682078-1682269 [Streptococcus sp. HN38]
MPLTGKEMAKLAEANGWKEIRVNGSHHHFKKEGFSKIVTIPVHGNKDLGKGLEKKILRDLGLL

Download         Length: 192 bp

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14195.03 Da        Isoelectric Point: 4.2530

>AT269071 WP_024375896.1 NZ_CP116604:1682305-1682682 [Streptococcus sp. HN38]
MLKSYPAIFHKDEQGYWVEFPEFSGGTQGDNLEEAMYNARDFLESSIALYIDEGMELPKVSDIKELSAPDGFVSMIQADP
TPYIKNNKAIRKNVTVPEWLTKLADREGLNYSEILTTALETRLQV

Download         Length: 378 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M9FK57

Antitoxin

Source ID Structure
AlphaFold DB A0A0M9FJP6

References