Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1596640..1597309 Replicon chromosome
Accession NZ_CP116604
Organism Streptococcus sp. HN38

Toxin (Protein)


Gene name hicA Uniprot ID G7SGM1
Locus tag PHA78_RS07600 Protein ID WP_014637653.1
Coordinates 1597127..1597309 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0Z8N440
Locus tag PHA78_RS07595 Protein ID WP_024376647.1
Coordinates 1596640..1597089 (-) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PHA78_RS07580 1592468..1594333 - 1866 WP_272157926.1 C69 family dipeptidase -
PHA78_RS07585 1594422..1595282 - 861 WP_024378591.1 SAM-dependent methyltransferase TehB -
PHA78_RS07590 1595436..1596479 + 1044 WP_024378592.1 Zn-dependent alcohol dehydrogenase -
PHA78_RS07595 1596640..1597089 - 450 WP_024376647.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PHA78_RS07600 1597127..1597309 - 183 WP_014637653.1 type II toxin-antitoxin system HicA family toxin Toxin
PHA78_RS07605 1597474..1598040 - 567 WP_024378593.1 hypothetical protein -
PHA78_RS07610 1598054..1598272 - 219 WP_029175784.1 hypothetical protein -
PHA78_RS07615 1598819..1599286 - 468 WP_014637647.1 SsrA-binding protein SmpB -
PHA78_RS07620 1599289..1601658 - 2370 WP_272157927.1 ribonuclease R -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6653.87 Da        Isoelectric Point: 10.8207

>T269070 WP_014637653.1 NZ_CP116604:c1597309-1597127 [Streptococcus sp. HN38]
MPMTQKEMVKLLTAHGWTKTKGGKGSHVKLEKAGERPITIPHGEINKYTERGIKKQAGLL

Download         Length: 183 bp

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16620.63 Da        Isoelectric Point: 4.0193

>AT269070 WP_024376647.1 NZ_CP116604:c1597089-1596640 [Streptococcus sp. HN38]
MLVTYPALFYFDDTDGANAPYFVTFPDFEHSATQGEDMADAMAMASDWLGINLADYIENGRDIPTPSSINTLSLVDNNPF
RNEDFEMVYDSSKSFISMVMVDVAKYLGSQEPVKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKLHA

Download         Length: 450 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G7SGM1

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8N440

References