Detailed information of TA system TA026907

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 1685409..1686025
• Replicon: chromosome
• Accession: NC_017524
• Organism: Mycobacterium tuberculosis CTRI-2

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: MTCTRI2_RS07930
• Protein ID: WP_014585518.1
• Coordinates: 1685708..1686025 (+)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: G0TJ73
• Locus tag: MTCTRI2_RS07925
• Protein ID: WP_003900349.1
• Coordinates: 1685409..1685711 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTCTRI2_RS07915	1681295..1683142	+	1848	WP_003407585.1	methylmalonyl-CoA mutase small subunit	-
MTCTRI2_RS07920	1683143..1685395	+	2253	WP_003407587.1	methylmalonyl-CoA mutase	-
MTCTRI2_RS07925	1685409..1685711	+	303	WP_003900349.1	type II toxin-antitoxin system antitoxin MazE4	Antitoxin
MTCTRI2_RS07930	1685708..1686025	+	318	WP_014585518.1	type II toxin-antitoxin system toxin endoribonuclease MazF4	Toxin
MTCTRI2_RS07935	1686022..1687026	+	1005	WP_003407596.1	methylmalonyl Co-A mutase-associated GTPase MeaB	-
MTCTRI2_RS07940	1687079..1688368	+	1290	WP_003407599.1	serine hydrolase	-
MTCTRI2_RS07945	1688441..1689214	-	774	WP_003912632.1	class I SAM-dependent methyltransferase	-
MTCTRI2_RS07950	1689272..1689484	-	213	WP_003898900.1	dodecin family protein	-
MTCTRI2_RS22430	1689494..1689796	-	303	WP_003407610.1	NUDIX domain-containing protein	-
MTCTRI2_RS07960	1689988..1691016	+	1029	WP_003407612.1	glycosyltransferase family 2 protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (4-102)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 11477.10 Da
• Isoelectric Point: 8.9427

>T26907 WP_014585518.1 NC_017524:1685708-1686025 [Mycobacterium tuberculosis CTRI-2]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTRYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Nucleotide

• Length: 318 bp

>T26907 NC_017524:1685708-1686025 [Mycobacterium tuberculosis CTRI-2]
GTGAACGCGCCGTTGCGTGGTCAGGTCTATCGATGCGACCTCGGATACGGGGCCAAACCGTGGCTCATCGTCTCCAACAA
CGCCCGCAACCGTCACACCGCCGACGTGGTGGCTGTGCGCCTGACAACAACGCGGAGAACCATACCGACCTGGGTCGCCA
TGGGCCCCAGCGATCCATTGACCCGATACGTCAACGCGGACAACATCGAGACCCTCGGCAAAGACGAGCTCGGTGACTAC
CTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACCGCGCTGGGGCTACCGTGGCCATGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11173.42 Da
• Isoelectric Point: 9.5564

>AT26907 WP_003900349.1 NC_017524:1685409-1685711 [Mycobacterium tuberculosis CTRI-2]
VPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Nucleotide

• Length: 303 bp

>AT26907 NC_017524:1685409-1685711 [Mycobacterium tuberculosis CTRI-2]
GTGCCGTTTCTGGTTGCATTATCCGGTATCATCTCGGGCGTGCGTGATCATTCGATGACCGTGCGGCTCGACCAGCAAAC
TCGCCAGCGCCTGCAAGACATTGTGAAAGGCGGATACCGGAGCGCTAATGCGGCGATCGTCGACGCCATCAACAAGCGCT
GGGAGGCGCTACACGATGAGCAACTCGACGCCGCCTACGCGGCCGCGATCCATGACAATCCGGCGTACCCGTACGAGTCT
GAGGCCGAACGGAGCGCCGCGCGGGCCCGGCGCAACGCCAGGCAGCAGCGCTCGGCACAGTGA

Structures

Antitoxin

• PDB: 5XE3
• AlphaFold DB: G0TJ73