Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1053288..1053780 Replicon chromosome
Accession NZ_CP116604
Organism Streptococcus sp. HN38

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag PHA78_RS05195 Protein ID WP_024415808.1
Coordinates 1053523..1053780 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8GIU7
Locus tag PHA78_RS05190 Protein ID WP_024385224.1
Coordinates 1053288..1053539 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PHA78_RS05165 1048349..1049515 + 1167 WP_272158517.1 ATP-grasp domain-containing protein -
PHA78_RS05170 1049920..1050060 + 141 WP_032499492.1 hypothetical protein -
PHA78_RS05175 1050073..1050456 + 384 WP_024418298.1 NisI/SpaI family lantibiotic immunity lipoprotein -
PHA78_RS05180 1050473..1051225 + 753 WP_104929962.1 ABC transporter ATP-binding protein -
PHA78_RS05185 1051226..1053196 + 1971 WP_272158518.1 FtsX-like permease family protein -
PHA78_RS05190 1053288..1053539 + 252 WP_024385224.1 DUF6290 family protein Antitoxin
PHA78_RS05195 1053523..1053780 + 258 WP_024415808.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PHA78_RS05200 1053820..1054488 + 669 WP_024415807.1 response regulator transcription factor -
PHA78_RS05205 1054485..1055426 + 942 WP_272158519.1 sensor histidine kinase -
PHA78_RS05210 1055501..1057009 + 1509 WP_272158520.1 phosphomannomutase/phosphoglucomutase -
PHA78_RS05215 1057072..1058142 - 1071 WP_272158521.1 tyrosine recombinase XerS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-73)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9900.46 Da        Isoelectric Point: 10.8924

>T269069 WP_024415808.1 NZ_CP116604:1053523-1053780 [Streptococcus sp. HN38]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKVTATSLKM
RNGSI

Download         Length: 258 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9424.64 Da        Isoelectric Point: 3.7128

>AT269069 WP_024385224.1 NZ_CP116604:1053288-1053539 [Streptococcus sp. HN38]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIAWAEYQEDLANGIEPISWEEMLEELGLTNE
DLL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8GIU7

References