269068

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-couple_hipB
Location 286773..288025 Replicon chromosome
Accession NZ_CP116604
Organism Streptococcus sp. HN38

Toxin (Protein)


Gene name sezT Uniprot ID -
Locus tag PHA78_RS01465 Protein ID WP_272158365.1
Coordinates 287249..288025 (+) Length 259 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag PHA78_RS01460 Protein ID WP_272158364.1
Coordinates 286773..287249 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PHA78_RS01425 281934..282260 - 327 WP_002937550.1 PadR family transcriptional regulator -
PHA78_RS01430 282553..282933 + 381 WP_043025465.1 CidA/LrgA family protein -
PHA78_RS01435 282926..283621 + 696 WP_024377398.1 LrgB family protein -
PHA78_RS01440 283655..284455 - 801 WP_105129917.1 formate/nitrite transporter family protein -
PHA78_RS01445 284595..285440 + 846 WP_024418726.1 MIP/aquaporin family protein -
PHA78_RS01450 285629..285781 + 153 Protein_253 DUF853 family protein -
PHA78_RS01455 285911..286525 + 615 WP_024378038.1 CoA pyrophosphatase -
PHA78_RS01460 286773..287249 + 477 WP_272158364.1 type II toxin-antitoxin system antitoxin PezA Antitoxin
PHA78_RS01465 287249..288025 + 777 WP_272158365.1 type II toxin-antitoxin system toxin PezT Toxin
PHA78_RS01470 288161..288325 + 165 WP_180273797.1 hypothetical protein -
PHA78_RS01475 288444..289211 + 768 WP_029185508.1 DeoR/GlpR family DNA-binding transcription regulator -
PHA78_RS01480 289416..289838 + 423 WP_002941127.1 galactose-6-phosphate isomerase subunit LacA -
PHA78_RS01485 289865..290380 + 516 WP_002941130.1 galactose-6-phosphate isomerase subunit LacB -
PHA78_RS01490 290390..291322 + 933 WP_024378035.1 tagatose-6-phosphate kinase -
PHA78_RS01495 291324..292301 + 978 WP_024378034.1 tagatose-bisphosphate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(28-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 259 a.a.        Molecular weight: 29487.31 Da        Isoelectric Point: 5.9866

>T269068 WP_272158365.1 NZ_CP116604:287249-288025 [Streptococcus sp. HN38]
MRLEEFSEVEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDELSKRGYHLLIEGTLRTTQVPRQTAQLLTSKGYQVSLAIIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKDHHDGIVENLVDNLRELESDKIFDRIQIYQRDRTCIYDSETDDGSAAEVLQNCLFGDWSKVEEEMM
KVGRERLREMSKSNENDV

Download         Length: 777 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18216.67 Da        Isoelectric Point: 4.4582

>AT269068 WP_272158364.1 NZ_CP116604:286773-287249 [Streptococcus sp. HN38]
MIGDSIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLKIE
VIKERGAAILSQLYRYQDSQGIAFDDETNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLDMVHHRVVA

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References