269067

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2090826..2092582 Replicon chromosome
Accession NZ_CP116600
Organism Burkholderia pseudomallei strain MSHR5089

Toxin (Protein)


Gene name doc Uniprot ID C4APV8
Locus tag AQ936_RS09015 Protein ID WP_004195452.1
Coordinates 2090826..2091731 (+) Length 302 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q63LW2
Locus tag AQ936_RS09020 Protein ID WP_004195450.1
Coordinates 2091728..2092582 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AQ936_RS08985 (AQ936_008985) 2086221..2087309 - 1089 WP_004184835.1 porin -
AQ936_RS08990 (AQ936_008990) 2087744..2088061 + 318 WP_004184916.1 non-heme iron oxygenase ferredoxin subunit -
AQ936_RS08995 (AQ936_008995) 2088063..2088374 + 312 WP_038735665.1 hypothetical protein -
AQ936_RS09000 (AQ936_009000) 2088409..2089476 + 1068 WP_004195457.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
AQ936_RS09005 (AQ936_009005) 2089473..2090243 + 771 WP_004524000.1 SDR family oxidoreductase -
AQ936_RS09010 (AQ936_009010) 2090282..2090809 + 528 WP_004524001.1 cupin domain-containing protein -
AQ936_RS09015 (AQ936_009015) 2090826..2091731 + 906 WP_004195452.1 alpha/beta fold hydrolase Toxin
AQ936_RS09020 (AQ936_009020) 2091728..2092582 + 855 WP_004195450.1 IclR family transcriptional regulator Antitoxin
AQ936_RS09025 (AQ936_009025) 2092579..2093376 + 798 WP_004540865.1 SDR family oxidoreductase -
AQ936_RS09030 (AQ936_009030) 2093369..2095042 + 1674 WP_004524004.1 thiamine pyrophosphate-binding protein -
AQ936_RS09035 (AQ936_009035) 2095035..2095850 + 816 WP_004195445.1 aspartate dehydrogenase -
AQ936_RS09040 (AQ936_009040) 2095876..2097366 + 1491 WP_004524006.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(54-284)

Antitoxin

Transcription regulator IclR, C-terminal

(143-265)


Sequences

Toxin        


Download         Length: 302 a.a.        Molecular weight: 30555.70 Da        Isoelectric Point: 8.7357

>T269067 WP_004195452.1 NZ_CP116600:2090826-2091731 [Burkholderia pseudomallei]
MSTISTTTTEAGAAPFAALLARFPERRAAVGGAGVIGYREAGEAHARRAGCEPVVLLHGIGSGAASWVRQLDALGATRRA
LAWDAPGYGASSRVAADSPVAADYAASLAAWLDALRIQRCVLVGHSLGAIMAGAFARIAGERLAGLLLISPAGGYGSAPA
DVRAGRRDSRLALLASLGPQGLAAERSANMLSAQASGAAREWVRWNMARIAPAGYAQATHLLANADLASDLAHCRGRIAV
AVGGDDAITPPAACERIARAAGVGLQVIARAGHAGYVEAPDAYSALIDAFCRQCDGSRGTP

Download         Length: 906 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31152.56 Da        Isoelectric Point: 6.8932

>AT269067 WP_004195450.1 NZ_CP116600:2091728-2092582 [Burkholderia pseudomallei]
MSEPLLKDADDARNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTAHIVIRDGRDVVFVAKAQNAGNAFGSVRVNVGTRLPAHATTHGHV
LMGDLSLAQLRALYPERALERVTKATPETVDALFDVIRDDARRGYGIGNSAFERDISVVTAPVRNEASRIVAVVTVTVPR
PEIDAALVAEGLVEKVVRAAAELSRRLNYRSDDENTYLKALGLR

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3N4FRK3

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4FRW8

References